Universität zu Köln

Hof, Alexander ORCID: 0000-0001-6554-8892, Landerer, Max, Peitsmeyer, Philipp, Herzog, Ronja, Alber, Jens, Ahdab, Maysam ORCID: 0009-0008-8160-4186, Nettersheim, Felix Sebastian ORCID: 0000-0002-4090-3357, Mehrkens, Dennis ORCID: 0000-0002-8578-0290, Geißen, Simon ORCID: 0000-0002-7835-4111, Braumann, Simon ORCID: 0000-0002-9969-6073, Guthoff, Henning ORCID: 0000-0002-0979-1190, von Stein, Philipp ORCID: 0000-0003-4548-3897, Nemade, Harshal ORCID: 0000-0002-2704-181X, Picard, Felix Simon Ruben ORCID: 0000-0001-7624-4704, Braun, Ramona, Hoyer, Friedrich Felix, Brüning, Jens Claus ORCID: 0000-0003-1333-2031, Pfeifer, Alexander, Hildebrand, Staffan, Winkels, Holger, Baldus, Stephan ORCID: 0000-0001-8259-1737, Adam, Matti ORCID: 0000-0002-6990-8135, Schäkel, Jasper and Mollenhauer, Martin ORCID: 0000-0002-3220-9269 (2025). Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Reports Medicine, 6 (5). pp. 1-18. Elsevier. ISSN 26663791

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Abstract

[Artikel-Nr.: 102087] Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflamma- tion in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cells, including myeloperoxidase (MPO)-releasing myeloid cells, accumulate in PVAT. In this study, we show MPO levels to correlate with body weight and endothelial function in obese patients (n = 33) and mice. In addition, MPO deficiency reduces immune cell frequency, enhances PVAT beiging via soluble guanylyl cyclase b1 (sGC-b1), and increases oxygen consumption in vivo. Further, nitrotyrosine formation and inflammatory cytokine release are attenuated in obese Mpo�/� mice. Mechanistically, adiponectin (APN) secretion improves endothelial function and reduces arterial stiffness. In vitro, MPO-treated human white adipocytes show lower APN and brown adipocyte marker expression but increased inflammation. Thus, MPO impairs vascular function via PVAT inflammation and suppression of vasoprotective mediators, making it a potential therapeutic target in obesity-related cardiovascular disease.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Hof, Alexander UNSPECIFIED https://orcid.org/0000-0001-6554-8892 UNSPECIFIED Landerer, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Peitsmeyer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, Ronja UNSPECIFIED UNSPECIFIED UNSPECIFIED Alber, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahdab, Maysam UNSPECIFIED https://orcid.org/0009-0008-8160-4186 UNSPECIFIED Nettersheim, Felix Sebastian UNSPECIFIED https://orcid.org/0000-0002-4090-3357 UNSPECIFIED Mehrkens, Dennis UNSPECIFIED https://orcid.org/0000-0002-8578-0290 UNSPECIFIED Geißen, Simon UNSPECIFIED https://orcid.org/0000-0002-7835-4111 UNSPECIFIED Braumann, Simon UNSPECIFIED https://orcid.org/0000-0002-9969-6073 UNSPECIFIED Guthoff, Henning UNSPECIFIED https://orcid.org/0000-0002-0979-1190 UNSPECIFIED von Stein, Philipp UNSPECIFIED https://orcid.org/0000-0003-4548-3897 UNSPECIFIED Nemade, Harshal hnemade@uni-koeln.de https://orcid.org/0000-0002-2704-181X UNSPECIFIED Picard, Felix Simon Ruben UNSPECIFIED https://orcid.org/0000-0001-7624-4704 UNSPECIFIED Braun, Ramona UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer, Friedrich Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Brüning, Jens Claus UNSPECIFIED https://orcid.org/0000-0003-1333-2031 UNSPECIFIED Pfeifer, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Hildebrand, Staffan UNSPECIFIED UNSPECIFIED UNSPECIFIED Winkels, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED https://orcid.org/0000-0001-8259-1737 UNSPECIFIED Adam, Matti UNSPECIFIED https://orcid.org/0000-0002-6990-8135 UNSPECIFIED Schäkel, Jasper UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, Martin UNSPECIFIED https://orcid.org/0000-0002-3220-9269 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-802902
Identification Number:	10.1016/j.xcrm.2025.102087
Journal or Publication Title:	Cell Reports Medicine
Volume:	6
Number:	5
Page Range:	pp. 1-18
Number of Pages:	18
Date:	20 May 2025
Publisher:	Elsevier
ISSN:	26663791
Language:	English
Faculty:	External institution Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > MPI for Metabolism Research Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin Zentrum für Molekulare Medizin
Subjects:	Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80290