Universität zu Köln

Prinz, Julia, Epping, Carla-Maria, Kuerten, David, Fuest, Matthias, Cursiefen, Claus ORCID: 0000-0002-1958-411X, Walter, Peter, Mercieca, Karl and Prokosch, Verena ORCID: 0000-0002-5318-0637 (2025). Preoperative predictive thresholds for successful canaloplasty in glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology, 263 (10). pp. 2867-2874. Springer Nature. ISSN 0721-832X

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Abstract

Purpose: To establish preoperative thresholds of intraocular pressure (IOP) levels and the number of IOP-lowering eye drops that predict the surgical success of canaloplasty. Methods This retrospective study included 166 glaucoma patients undergoing canaloplasty. Data on age, sex, glaucoma subtype, visual acuity, IOP, number of IOP-lowering eye drops, intraoperative and postoperative complications, and reoperations were collected during a 12-month follow-up period. Logistic regression models were applied to identify preoperative thresholds associated with an increased risk of surgical failure. Results: At 12 months, mean IOP decreased from 24.2 ± 7.8 to 14.8 ± 3.7 mmHg, and the number of IOP-lowering eye drops from 2.3 ± 1.1 to 0.6 ± 1.0 (both p < 0.001). For success rates ≤ 18 and ≤ 15 mmHg, logistic regression identified a preoperative IOP threshold of 36.9 and 27.1 mmHg (qualified success), and 27.1 and 20.1 mmHg (complete success), respectively, above which the likelihood of surgical failure increased. No significant association was found between the number of preoperative IOP-lowering eye drops and surgical success. No long-term postoperative complications were recorded. Conclusions: In patients with preoperative IOPs of ≤ 36.9 mmHg or 27.1 mmHg, canaloplasty is likely to be an effective and safe procedure to obtain target pressures ≤ 18 mmHg with or without IOP-lowering eye drops, respectively. These data suggest that preoperative thresholds could help predict postoperative outcomes and improve patient selection for glaucoma surgery.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Prinz, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Epping, Carla-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuest, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED https://orcid.org/0000-0002-1958-411X UNSPECIFIED Walter, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mercieca, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED https://orcid.org/0000-0002-5318-0637 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-802980
Identification Number:	10.1007/s00417-025-06887-6
Journal or Publication Title:	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume:	263
Number:	10
Page Range:	pp. 2867-2874
Number of Pages:	8
Date:	4 October 2025
Publisher:	Springer Nature
ISSN:	0721-832X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Augenheilkunde > Klinik und Poliklinik für Allgemeine Augenheilkunde
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Glaucoma ; Canaloplasty ; Intraocular pressure ; Logistic regression English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80298