Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Aboian, Mariam, Barajas, Ramon F ORCID: 0000-0001-5093-4168, Breen, William G ORCID: 0000-0001-8039-2398, Ivanidze, Jana ORCID: 0000-0002-6470-5400, Johnson, Derek R ORCID: 0000-0002-4217-5517, Kaufmann, Timothy J ORCID: 0000-0001-7483-1569, Kim, Michelle M ORCID: 0000-0001-7566-6411, Mair, Maximilian J ORCID: 0000-0002-6537-3874, Minniti, Giuseppe ORCID: 0000-0003-1239-1603, Müther, Michael ORCID: 0000-0001-9427-5555, Nabavizadeh, Ali ORCID: 0000-0002-0380-4552, Palmer, Joshua D ORCID: 0000-0003-3311-0129, Rudà, Roberta ORCID: 0000-0001-9134-1537, Smits, Marion ORCID: 0000-0001-5563-2871, Tolboom, Nelleke ORCID: 0000-0002-8005-2833, Veldhuijzen van Zanten, Sophie E M ORCID: 0000-0002-3888-0977, Veronesi, Michael C ORCID: 0000-0001-8551-151X, Werner, Jan-Michael ORCID: 0000-0001-7147-4594, van den Bent, Martin ORCID: 0000-0001-5710-5127, Chang, Susan M ORCID: 0009-0001-2084-3959, Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Law, Ian ORCID: 0000-0001-9644-7496, McConathy, Jonathan ORCID: 0000-0003-4681-2322, Mehta, Minesh, Preusser, Matthias ORCID: 0000-0003-3541-2315, Short, Susan C, Soffietti, Riccardo, Vogelbaum, Michael ORCID: 0000-0002-9833-2374, Weller, Michael ORCID: 0000-0002-1748-174X, Wen, Patrick Y ORCID: 0000-0002-0774-7700, Tonn, Joerg-Christian ORCID: 0009-0004-1756-423X and Albert, Nathalie L ORCID: 0000-0003-0953-7624 (2025). Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas. The Lancet Oncology, 26 (8). e436-e447. Elsevier. ISSN 1470-2045

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Abstract

This Policy Review provides recommendations for the use of PET imaging in patients with gliomas and represents a joint effort of the Response Assessment in Neuro-Oncology (RANO) working group for PET and the European Association for Neuro-Oncology. The initial guideline was published in 2016, and summarised the previously established clinical benefit of PET with radiolabelled glucose and amino acid tracers in patients with gliomas. Since then, numerous additional studies have been published on this topic, focusing on differential diagnosis, prediction of molecular information, and prognostication. Further studies evaluated PET for biopsy guidance and delineation of glioma extent for local therapy planning, including resection and radiotherapy. In patients undergoing treatment, PET was studied for the assessment of response to local and systemic treatments and PET-based standardised response criteria (PET RANO 1.0) were proposed. In this Policy Review, the updated recommendations are based on evidence generated from studies that validated PET findings by histomolecular findings or clinical course. This guideline further underscores the previously reported clinical value of PET imaging and the superiority of amino acid PET over glucose PET, providing a framework for the use of PET in the management of patients with gliomas. The guideline also underscores the scarcity of class 1 evidence showing that incorporating PET imaging into clinical workflows improves patient outcomes, highlighting priority areas for future clinical studies designed to address this gap.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED https://orcid.org/0000-0002-2485-1796 UNSPECIFIED Lohmann, Philipp UNSPECIFIED https://orcid.org/0000-0002-5360-046X UNSPECIFIED Aboian, Mariam UNSPECIFIED UNSPECIFIED UNSPECIFIED Barajas, Ramon F UNSPECIFIED https://orcid.org/0000-0001-5093-4168 UNSPECIFIED Breen, William G UNSPECIFIED https://orcid.org/0000-0001-8039-2398 UNSPECIFIED Ivanidze, Jana UNSPECIFIED https://orcid.org/0000-0002-6470-5400 UNSPECIFIED Johnson, Derek R UNSPECIFIED https://orcid.org/0000-0002-4217-5517 UNSPECIFIED Kaufmann, Timothy J UNSPECIFIED https://orcid.org/0000-0001-7483-1569 UNSPECIFIED Kim, Michelle M UNSPECIFIED https://orcid.org/0000-0001-7566-6411 UNSPECIFIED Mair, Maximilian J UNSPECIFIED https://orcid.org/0000-0002-6537-3874 UNSPECIFIED Minniti, Giuseppe UNSPECIFIED https://orcid.org/0000-0003-1239-1603 UNSPECIFIED Müther, Michael UNSPECIFIED https://orcid.org/0000-0001-9427-5555 UNSPECIFIED Nabavizadeh, Ali UNSPECIFIED https://orcid.org/0000-0002-0380-4552 UNSPECIFIED Palmer, Joshua D UNSPECIFIED https://orcid.org/0000-0003-3311-0129 UNSPECIFIED Rudà, Roberta UNSPECIFIED https://orcid.org/0000-0001-9134-1537 UNSPECIFIED Smits, Marion UNSPECIFIED https://orcid.org/0000-0001-5563-2871 UNSPECIFIED Tolboom, Nelleke UNSPECIFIED https://orcid.org/0000-0002-8005-2833 UNSPECIFIED Veldhuijzen van Zanten, Sophie E M UNSPECIFIED https://orcid.org/0000-0002-3888-0977 UNSPECIFIED Veronesi, Michael C UNSPECIFIED https://orcid.org/0000-0001-8551-151X UNSPECIFIED Werner, Jan-Michael UNSPECIFIED https://orcid.org/0000-0001-7147-4594 UNSPECIFIED van den Bent, Martin UNSPECIFIED https://orcid.org/0000-0001-5710-5127 UNSPECIFIED Chang, Susan M UNSPECIFIED https://orcid.org/0009-0001-2084-3959 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED https://orcid.org/0000-0003-1101-5075 UNSPECIFIED Law, Ian UNSPECIFIED https://orcid.org/0000-0001-9644-7496 UNSPECIFIED McConathy, Jonathan UNSPECIFIED https://orcid.org/0000-0003-4681-2322 UNSPECIFIED Mehta, Minesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Preusser, Matthias UNSPECIFIED https://orcid.org/0000-0003-3541-2315 UNSPECIFIED Short, Susan C UNSPECIFIED UNSPECIFIED UNSPECIFIED Soffietti, Riccardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogelbaum, Michael UNSPECIFIED https://orcid.org/0000-0002-9833-2374 UNSPECIFIED Weller, Michael UNSPECIFIED https://orcid.org/0000-0002-1748-174X UNSPECIFIED Wen, Patrick Y UNSPECIFIED https://orcid.org/0000-0002-0774-7700 UNSPECIFIED Tonn, Joerg-Christian UNSPECIFIED https://orcid.org/0009-0004-1756-423X UNSPECIFIED Albert, Nathalie L UNSPECIFIED https://orcid.org/0000-0003-0953-7624 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-803156
Identification Number:	10.1016/S1470-2045(25)00193-7
Journal or Publication Title:	The Lancet Oncology
Volume:	26
Number:	8
Page Range:	e436-e447
Number of Pages:	12
Date:	August 2025
Publisher:	Elsevier
ISSN:	1470-2045
Language:	English
Faculty:	External institution Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO)
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80315