Universität zu Köln

Kernich, Nikolaus, Abi-Chokami, Arian, Jung, Norma ORCID: 0000-0002-5740-0772, Jochimsen, Dorothee, Sircar, Krishnan ORCID: 0000-0001-8865-8795, Hoffmann, Ada Marie ORCID: 0000-0002-3093-8417, Meuser, Stefan, Eysel, Peer ORCID: 0009-0004-6057-6092, Weber, Carolyn, Vinas-Rios, Juan Manuel, Yagdiran, Ayla ORCID: 0000-0002-1723-5995, Jung, Norma ORCID: 0000-0002-5740-0772, Yagdiran, Ayla ORCID: 0000-0002-1723-5995, Kernich, Nikolaus, Sircar, Krishnan ORCID: 0000-0001-8865-8795, Fischer, Julia ORCID: 0000-0001-6138-7454, Jochimsen, Dorothee, Weber, Carolyn and Meyer-Schwickerath, Charlotte ORCID: 0000-0001-6711-6516 (2025). Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis. Infection, 53 (5). pp. 2025-2035. Springer Nature. ISSN 0300-8126

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Abstract

Objective: Vertebral osteomyelitis (VO) is a severe clinical entity associated with high mortality rates, especially within the first year after diagnosis. The aim of this single-center prospective cohort study was to identify and compare predictive factors influencing early and late mortality in patients with conservatively and surgically treated VO. Methods We conducted a single-center prospective cohort study including patients treated for VO between 2008 and 2020 in a tertiary center in Germany to determine early (death within 30 days after diagnosis) and late mortality (death between day 31 and 365 after diagnosis). Additionally, multivariable analyses were performed to analyze predictive risk factors for early and late mortality. Results: A total of 323 patients were included. 19% died within the first year after diagnosis. Early mortality occurred in 5% and late mortality in 14% of cases. Multivariable analysis revealed chronic kidney disease (CKD) (OR: 13.2, 95% CI 5.7–30.3; p < 0.001) and MSSA (OR: 4.0, 95% CI 1.4–11.1; p = 0.008) as independent risk factors for early mortality, whereas ASA score > 2 (HR: 5.2, 95% CI 2.6–10.6; p < 0.001), age > 70 years (HR: 2.4, 95% CI 1.6–3.7; p < 0.001), CKD (HR: 1.9, 95% CI 1.3–3.0; p = 0.003) and bacteremia (HR: 1.8, 95% CI 1.2–2.7; p = 0.002) were identified as independent risk factors for late mortality. Conclusion: One out of five VO patients dies within the first year after diagnosis. Risk factors for mortality within the first year include CKD and bacteremia. As a consequence in particular those patients should be closely monitored within the first year after.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kernich, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Abi-Chokami, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Norma UNSPECIFIED https://orcid.org/0000-0002-5740-0772 UNSPECIFIED Jochimsen, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Sircar, Krishnan UNSPECIFIED https://orcid.org/0000-0001-8865-8795 UNSPECIFIED Hoffmann, Ada Marie UNSPECIFIED https://orcid.org/0000-0002-3093-8417 UNSPECIFIED Meuser, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED https://orcid.org/0009-0004-6057-6092 UNSPECIFIED Weber, Carolyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Vinas-Rios, Juan Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Yagdiran, Ayla UNSPECIFIED https://orcid.org/0000-0002-1723-5995 UNSPECIFIED Jung, Norma UNSPECIFIED https://orcid.org/0000-0002-5740-0772 UNSPECIFIED Yagdiran, Ayla UNSPECIFIED https://orcid.org/0000-0002-1723-5995 UNSPECIFIED Kernich, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Sircar, Krishnan UNSPECIFIED https://orcid.org/0000-0001-8865-8795 UNSPECIFIED Fischer, Julia UNSPECIFIED https://orcid.org/0000-0001-6138-7454 UNSPECIFIED Jochimsen, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Carolyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-Schwickerath, Charlotte UNSPECIFIED https://orcid.org/0000-0001-6711-6516 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-803359
Identification Number:	10.1007/s15010-025-02541-9
Journal or Publication Title:	Infection
Volume:	53
Number:	5
Page Range:	pp. 2025-2035
Number of Pages:	11
Date:	9 October 2025
Publisher:	Springer Nature
ISSN:	0300-8126
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Orthopädie > Klinik und Poliklinik für Orthopädie und Unfallchirurgie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Vertebral osteomyelitis ; Spondylodiscitis ; Surgery ; Early mortality ; Late mortality ; Risk factors English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80335