Universität zu Köln

Lukas, Dominika ORCID: 0000-0002-9867-0891, Liu, Xinyuan ORCID: 0000-0002-0442-0112, Reibetanz, Marion ORCID: 0000-0001-5250-5180, Könen-Waisman, Stephanie ORCID: 0000-0002-4794-9534, Bopp, Tobias ORCID: 0000-0002-3232-8065, Bohn, Toszka ORCID: 0009-0009-2738-2807, Vivier, Eric ORCID: 0000-0001-7022-8287, Gasteiger, Georg ORCID: 0000-0001-6986-127X, Waisman, Ari ORCID: 0000-0003-4304-8234 and von Stebut, Esther ORCID: 0000-0001-9802-9642 (2025). Innate Lymphoid Cell 1– and NK Cell–Derived, Early IFNg Release Depends on ICER and Promotes Protection against Leishmania major Infection. Journal of Investigative Dermatology, 145 (12). pp. 3138-3144. Elsevier. ISSN 0022202X

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Abstract

Innate lymphoid cells (ILCs) participate in different skin diseases. Cutaneous leishmaniasis evokes T helper 1/cytotoxic T cell 1–dominated immunity, whereas in immune-compromised individuals, a T helper 2/regulatory T cell/T helper 17 immune response dominates. Only a few prior studies investigated the role of ILC in leishmaniasis. We show that after physiologic low-dose infection with Leishmania major, both lesional NK cell and ILC1 numbers strongly increase. In addition, early lesional IFNγ production derives from type I ILCs. Genetic ablation of both NK cells and ILC1 (NK/ILC1Δ mice) led to reduced early IFNγ expression, with increased pathology, higher parasite burdens, and delayed recovery. Furthermore, expression of ICER is important for disease outcome because Icer−/− mice exhibited significantly larger lesions. Interestingly, mice that lack ICER specifically in NK cells and ILC1 phenocopied the worsened disease outcome of Icer−/− mice, whereas ICER deficiency in T cells or macrophages alone failed to do so. In line, ICER deficiency in NK cells/ILC1 resulted in higher lesional parasite burden with fewer IFNγ-positive ILC1 than in control mice. Thus, our data show that both NK cells and ILC1 contribute to early parasite control by releasing IFNγ. ICER expression by ILC1 promotes recruitment of IFNγ+ ILC1 in Leishmania infections important for development of protection against this important pathogen.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Lukas, Dominika UNSPECIFIED https://orcid.org/0000-0002-9867-0891 UNSPECIFIED Liu, Xinyuan UNSPECIFIED https://orcid.org/0000-0002-0442-0112 UNSPECIFIED Reibetanz, Marion UNSPECIFIED https://orcid.org/0000-0001-5250-5180 UNSPECIFIED Könen-Waisman, Stephanie UNSPECIFIED https://orcid.org/0000-0002-4794-9534 UNSPECIFIED Bopp, Tobias UNSPECIFIED https://orcid.org/0000-0002-3232-8065 UNSPECIFIED Bohn, Toszka UNSPECIFIED https://orcid.org/0009-0009-2738-2807 UNSPECIFIED Vivier, Eric UNSPECIFIED https://orcid.org/0000-0001-7022-8287 UNSPECIFIED Gasteiger, Georg UNSPECIFIED https://orcid.org/0000-0001-6986-127X UNSPECIFIED Waisman, Ari UNSPECIFIED https://orcid.org/0000-0003-4304-8234 UNSPECIFIED von Stebut, Esther UNSPECIFIED https://orcid.org/0000-0001-9802-9642 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-803517
Identification Number:	10.1016/j.jid.2025.04.027
Journal or Publication Title:	Journal of Investigative Dermatology
Volume:	145
Number:	12
Page Range:	pp. 3138-3144
Number of Pages:	8
Date:	December 2025
Publisher:	Elsevier
ISSN:	0022202X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Dermatologie > Klinik und Poliklinik für Dermatologie und Venerologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language ICER ILC Leishmania major NK cell IFNγ English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80351