Universität zu Köln

Iliadis, Christos ORCID: 0000-0001-7655-8500, Adamo, Marianna, Rudolph, Volker, Karam, Nicole, von Bardeleben, Ralph Stephan, Anker, Stefan D., Delgado, Victoria, Hausleiter, Jörg, Kempton, Hannah, Metra, Marco, Böhm, Michael and Baldus, Stephan ORCID: 0000-0001-8259-1737 (2025). European Journal of Heart Failure Expert Consensus Statement on Transcatheter Treatment of Mitral Regurgitation in Heart Failure. European Journal of Heart Failure, 27 (11). pp. 2610-2622. Wiley. ISSN 1388-9842

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Abstract

Secondary mitral regurgitation (SMR) is highly prevalent in patients with heart failure (HF), associated with poor prognosis, and its treatment is typically preceded by implementing pharmacotherapy for HF as well as cardiac resynchronization therapy. Given the increase in experience and important technological iterations, transcatheter mitral valve repair has witnessed increasing safety and efficacy. Recently, two randomized controlled trials extended the level of evidence for this intervention in patients with SMR: RESHAPE-HF2 randomized patients with less severe SMR to either medical therapy alone versus adjunct transcatheter repair, whereas the MATTERHORN trial compared surgical therapy with transcatheter mitral valve repair in patients with SMR and increased risk for surgery. These two trials have a potential impact on the indications of transcatheter repair. Here we discuss updated indications for transcatheter mitral valve therapy across the different subtypes of SMR, revisit the current body of evidence for transcatheter mitral valve repair and classify this technique into the current treatment hierarchy of SMR in patients with HF.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Iliadis, Christos UNSPECIFIED https://orcid.org/0000-0001-7655-8500 UNSPECIFIED Adamo, Marianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Karam, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bardeleben, Ralph Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Anker, Stefan D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delgado, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausleiter, Jörg UNSPECIFIED UNSPECIFIED UNSPECIFIED Kempton, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Metra, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Böhm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED https://orcid.org/0000-0001-8259-1737 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-803567
Identification Number:	10.1002/ejhf.70043
Journal or Publication Title:	European Journal of Heart Failure
Volume:	27
Number:	11
Page Range:	pp. 2610-2622
Number of Pages:	13
Date:	1 November 2025
Publisher:	Wiley
ISSN:	1388-9842
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Consensus statement ; Heart failure ; Mitral valve ; Secondary mitral regurgitation ; Transcatheter edge-to-edge repair English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80356