Universität zu Köln

Burgmer, Sofie, Meyer zu Altenschildesche, Fenja L., Gyenis, Akos ORCID: 0000-0002-8104-7681, Lee, Hyun Ju, Vilchez, David ORCID: 0000-0002-0801-0743, Giavalisco, Patrick ORCID: 0000-0002-4636-1827, Fichant, Arnaud, Uhlirova, Mirka ORCID: 0000-0002-5735-8287 and Storelli, Gilles ORCID: 0000-0002-3558-390X (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Reports, 44 (6). pp. 1-26. Elsevier. ISSN 2211-1247

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Abstract

[Artikel-Nr.: 115811] Animals coexist with bacteria and need to keep these microorganisms under tight control. To achieve such control, pattern recognition receptors (PRRs) sense bacterial cues and induce the production of antimicro- bials. Here, we uncover a metabolic arm in the control of symbionts by PRRs. We show that, in Drosophila, the PRRs PGRP-LC and PGRP-LE act independently of canonical NF-κB signaling to repress essential meta- bolic functions in the gut, such as digestion and central carbon metabolism. This metabolic switch affects commensal populations and drastically reduces intestinal and systemic populations of the intracellular para- site Wolbachia. We propose that intestinal metabolic remodeling complements immune responses by imposing nutrient restriction on intracellular bacteria, whose lifestyle protects them from antimicrobials. Our findings reveal a role for PRRs in bacterial control beyond canonical immune pathways and provide insights into how microbial signals modulate symbiotic populations but also nutrition and metabolism in animals.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Burgmer, Sofie UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer zu Altenschildesche, Fenja L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gyenis, Akos UNSPECIFIED https://orcid.org/0000-0002-8104-7681 UNSPECIFIED Lee, Hyun Ju UNSPECIFIED UNSPECIFIED UNSPECIFIED Vilchez, David UNSPECIFIED https://orcid.org/0000-0002-0801-0743 UNSPECIFIED Giavalisco, Patrick UNSPECIFIED https://orcid.org/0000-0002-4636-1827 UNSPECIFIED Fichant, Arnaud UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhlirova, Mirka UNSPECIFIED https://orcid.org/0000-0002-5735-8287 UNSPECIFIED Storelli, Gilles UNSPECIFIED https://orcid.org/0000-0002-3558-390X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805316
Identification Number:	10.1016/j.celrep.2025.115811
Journal or Publication Title:	Cell Reports
Volume:	44
Number:	6
Page Range:	pp. 1-26
Number of Pages:	26
Date:	24 June 2025
Publisher:	Elsevier
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > MPI for Biology of Ageing CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	Life sciences Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Drosophila PGRP-LC and PGRP-LE bind bacterial peptidoglycanPGRP-LC and PGRP-LE suppress intestinal metabolism independently of Rel/NF-κB English These receptors act through Rel/NF-κB to induce an immune response in the gut English Metabolic remodeling curbs parasitic endosymbionts in the gut and peripheral organs English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80531