Universität zu Köln

Bopp, Luisa ORCID: 0000-0002-9089-5228, Deresz, Nicolai, Klapproth, Henning ORCID: 0000-0003-1966-3069, Suárez, Isabelle ORCID: 0000-0002-9863-9675, Jantsch, Jonathan ORCID: 0000-0001-6944-2913, Fabri, Mario ORCID: 0000-0002-9586-2230 and von Stebut, Esther ORCID: 0000-0001-9802-9642 (2026). Cutaneous non‐tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 24 (5). pp. 608-617. Wiley. ISSN 1610-0379

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Abstract

Background: Cutaneous non‐tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24‐year‐period. Patients and Methods: 73 patients with cutaneous NTM infections diagnosed at 17 different German University Hospitals from 2000–2011 and 21 patients treated at the Department of Dermatology of the University Hospital Cologne, from 2010–2024. Retrospective analysis of patient, demographic, clinical information, and data on different diagnostic workups and therapeutic approaches/responses. Results: Together, 94 cases were analyzed (71% males, mean age 50, > 75% immunocompetent). Exposure to fish tanks was the dominant risk factor. Pathogen detection by nucleic acid amplification test and/or culture was successful in 76%. The most common pathogen was Mycobacterium (M.) marinum (> 65%), followed by M. abscessus/chelonae . Immunosuppression was associated with NTM other than M. marinum . Over 90% were treated with oral antibiotics, in more than 50% with a single antibiotic (mostly clarithromycin). The most common combination was clarithromycin plus rifampicin. The mean duration of therapy was more than 4 months. Complications, adverse events, and relapses were rare. Conclusions: Our findings highlight that there is a need for standardized diagnostic procedures‐ and therapeutic recommendations for cutaneous NTM infections.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Bopp, Luisa UNSPECIFIED https://orcid.org/0000-0002-9089-5228 UNSPECIFIED Deresz, Nicolai UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapproth, Henning UNSPECIFIED https://orcid.org/0000-0003-1966-3069 UNSPECIFIED Suárez, Isabelle UNSPECIFIED https://orcid.org/0000-0002-9863-9675 UNSPECIFIED Jantsch, Jonathan UNSPECIFIED https://orcid.org/0000-0001-6944-2913 UNSPECIFIED Fabri, Mario UNSPECIFIED https://orcid.org/0000-0002-9586-2230 UNSPECIFIED von Stebut, Esther UNSPECIFIED https://orcid.org/0000-0001-9802-9642 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805554
Identification Number:	10.1111/ddg.15910
Journal or Publication Title:	JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Volume:	24
Number:	5
Page Range:	pp. 608-617
Number of Pages:	10
Date:	14 May 2026
Publisher:	Wiley
ISSN:	1610-0379
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Dermatologie > Klinik und Poliklinik für Dermatologie und Venerologie Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Medizinische Mikrobiologie, Immunologie und Hygiene > Institut für Medizinische Mikrobiologie, Immunologie und Hygiene Zentrum für Molekulare Medizin
Subjects:	Life sciences Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language fish tank granuloma ; Mycobacterium marinum ; mycobacteriae ; NTM UNSPECIFIED
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80555