Universität zu Köln

Asendorf, Adrian L. ORCID: 0000-0003-4261-330X, Guerra, Elena ORCID: 0009-0006-4641-0752, Dzialas, Verena ORCID: 0000-0001-7226-6674, Banwinkler, Magdalena ORCID: 0000-0001-7086-9973, Theis, Hendrik ORCID: 0000-0003-4661-5994, Hagemann, Niklas ORCID: 0000-0001-7751-9941, Möllenhoff, Kathrin ORCID: 0000-0001-7861-3892, van Eimeren, Thilo ORCID: 0000-0002-6951-2325 and Hoenig, Merle C. ORCID: 0000-0002-0831-750X (2025). Physical activity and network attack tolerance preserve motor function in Parkinson’s disease: A pilot study. npj Parkinson's Disease, 11 (1). pp. 1-9. Springer Nature. ISSN 2373-8057

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Abstract

[Artikel-Nr.: 183] We tested whether network resilience, quantified by network attack tolerance (NAT), is associated with dopamine terminal (DaT) integrity, motor function and lifestyle factors in Parkinson’s disease (PD). Data from 22 individuals with PD and 39 healthy controls included information on lifetime physical activity (PA), cognitive/motor performance, putaminal DaT integrity, and resting-state fMRI. NAT was assessed at global and subnetwork level by calculating global efficiency upon iterative node removal. Linear-mixed-effects models were used to test the effects of PA, education, and dopamine integrity on NAT. Next, the moderating effect of lifestyle factors on the association between NAT and motor function were assessed, controlling for DaT integrity. Greater putaminal DaT integrity was linked to higher somatomotor NAT. Higher global and somatomotor NAT supported motor function, especially in patients with moderate lifetime PA. These preliminary results indicate that lifestyle factors serve network-specific attack tolerance, thereby aiding maintenance of motor function in early-stage PD.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Asendorf, Adrian L. UNSPECIFIED https://orcid.org/0000-0003-4261-330X UNSPECIFIED Guerra, Elena UNSPECIFIED https://orcid.org/0009-0006-4641-0752 UNSPECIFIED Dzialas, Verena UNSPECIFIED https://orcid.org/0000-0001-7226-6674 UNSPECIFIED Banwinkler, Magdalena UNSPECIFIED https://orcid.org/0000-0001-7086-9973 UNSPECIFIED Theis, Hendrik UNSPECIFIED https://orcid.org/0000-0003-4661-5994 UNSPECIFIED Hagemann, Niklas UNSPECIFIED https://orcid.org/0000-0001-7751-9941 UNSPECIFIED Möllenhoff, Kathrin UNSPECIFIED https://orcid.org/0000-0001-7861-3892 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED https://orcid.org/0000-0002-6951-2325 UNSPECIFIED Hoenig, Merle C. UNSPECIFIED https://orcid.org/0000-0002-0831-750X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-806589
Identification Number:	10.1038/s41531-025-01033-9
Journal or Publication Title:	npj Parkinson's Disease
Volume:	11
Number:	1
Page Range:	pp. 1-9
Number of Pages:	9
Date:	28 June 2025
Publisher:	Springer Nature
ISSN:	2373-8057
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Medizinische Statistik und Bioinformatik > Institut für Medizinische Statistik und Bioinformatik � IMSB Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Nuklearmedizin > Klinik und Poliklinik für Nuklearmedizin
Subjects:	General statistics Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80658