Universität zu Köln

Wenzel, Marten C. ORCID: 0009-0009-0322-2577, Dasmeh, Pouria, Plum, Patrick S. ORCID: 0000-0002-8165-4553, Giel, Ann-Sophie, Hoppe, Sascha ORCID: 0000-0001-9246-3747, Franitza, Marek, Jonas, Christoph, Thieme, René, Zhao, Yue ORCID: 0000-0002-6790-3402, Heider, Dominik, Palles, Claire, Fitzgerald, Rebecca Claire, Bruns, Christiane J. ORCID: 0000-0001-6590-8181, Buettner, Reinhard ORCID: 0000-0001-8806-4786, Quaas, Alexander ORCID: 0000-0002-3537-6011, Gockel, Ines, Maj, Carlo, Chon, Seung-Hun ORCID: 0000-0002-8923-6428, Schumacher, Johannes and Hillmer, Axel M. ORCID: 0000-0002-3381-7266 (2025). Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition. Cell Genomics, 5 (10). pp. 1-19. Elsevier. ISSN 2666-979X

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Abstract

[Artikel-Nr.: 100980] Inherited genetic variants contribute to Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal tissues and integrated genome-wide association data to determine cell-type-specific genetic risk and cellular processes that contribute to BE and EAC. The analysis reveals that EAC development is driven to a greater extent by local cellular processes than BE development and suggests that one cell type of BE origin (intestinal metaplasia cells) and cellular processes that control the differentiation of columnar cells are of particular relevance for EAC development. Specific subtypes of fibroblasts and endothelial cells likely contribute to BE and EAC development, while dendritic cells and CD4+ memory T cells seem to contribute to BE development. The diagnostic value of markers characterizing the cell types and cellular processes should be explored for EAC prediction.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Wenzel, Marten C. UNSPECIFIED https://orcid.org/0009-0009-0322-2577 UNSPECIFIED Dasmeh, Pouria UNSPECIFIED UNSPECIFIED UNSPECIFIED Plum, Patrick S. UNSPECIFIED https://orcid.org/0000-0002-8165-4553 UNSPECIFIED Giel, Ann-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Sascha UNSPECIFIED https://orcid.org/0000-0001-9246-3747 UNSPECIFIED Franitza, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Thieme, René UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED https://orcid.org/0000-0002-6790-3402 UNSPECIFIED Heider, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Palles, Claire UNSPECIFIED UNSPECIFIED UNSPECIFIED Fitzgerald, Rebecca Claire UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED https://orcid.org/0000-0001-6590-8181 UNSPECIFIED Buettner, Reinhard UNSPECIFIED https://orcid.org/0000-0001-8806-4786 UNSPECIFIED Quaas, Alexander UNSPECIFIED https://orcid.org/0000-0002-3537-6011 UNSPECIFIED Gockel, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Maj, Carlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chon, Seung-Hun UNSPECIFIED https://orcid.org/0000-0002-8923-6428 UNSPECIFIED Schumacher, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillmer, Axel M. UNSPECIFIED https://orcid.org/0000-0002-3381-7266 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-806630
Identification Number:	10.1016/j.xgen.2025.100980
Journal or Publication Title:	Cell Genomics
Volume:	5
Number:	10
Page Range:	pp. 1-19
Number of Pages:	19
Date:	8 October 2025
Publisher:	Elsevier
ISSN:	2666-979X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80663