Universität zu Köln

Lyu, Su Ir ORCID: 0009-0002-4125-6048, Fretter, Caroline, Hillmer, Axel M. ORCID: 0000-0002-3381-7266, Grothey, Bastian ORCID: 0000-0002-0883-6481, Hoppe, Sascha ORCID: 0000-0001-9246-3747, Simon, Adrian Georg ORCID: 0000-0002-2709-863X, Zander, Thomas ORCID: 0000-0002-4266-6818, Knipper, Karl ORCID: 0009-0008-7133-3538, Schroeder, Wolfgang ORCID: 0000-0002-8700-069X, Bruns, Christiane J. ORCID: 0000-0001-6590-8181 and Quaas, Alexander ORCID: 0000-0002-3537-6011 (2025). Basal-like subtype of esophageal adenocarcinoma and it’s morphological, molecular and clinical characteristics. Scientific Reports, 15 (1). pp. 1-12. Springer Nature. ISSN 2045-2322

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Abstract

[Artikel-Nr.: 24680] Esophageal adenocarcinoma (EAC) and squamous cell carcinoma are the two main tumor types of the esophagus, each with distinct morphological and molecular features. While mixed adeno-squamous carcinomas are recognized, it remains unclear whether a basal-like subtype—known from breast and pancreatic adenocarcinomas—also exists in EAC. This study analyzed tumor samples from 953 patients with operable EAC for expression of the basal cytokeratins CK5 and CK6. Tumors with any squamous differentiation were excluded. A small subset (3.4%) showed a basal-like phenotype, characterized by high CK5 and/or CK6 expression and small-luminal tubular growth. High CK5 expression was associated with significantly worse overall survival, and within the neoadjuvantly treated subgroup, it emerged as an independent negative prognostic marker. Tumors with concurrent high CK5 and CK6 expression also showed reduced survival. Exploratory analyses revealed potential associations between CK6 expression and Claudin18.2 status, and between CK5 expression and Y-chromosome loss. These findings indicate the presence of a distinct basal-like subtype within EAC, linked to poor prognosis and possible molecular differences. CK5, alone or in combination with CK6, may serve as a practical biomarker for identifying this subtype and could support the development of more personalized treatment strategies.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Lyu, Su Ir UNSPECIFIED https://orcid.org/0009-0002-4125-6048 UNSPECIFIED Fretter, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillmer, Axel M. UNSPECIFIED https://orcid.org/0000-0002-3381-7266 UNSPECIFIED Grothey, Bastian UNSPECIFIED https://orcid.org/0000-0002-0883-6481 UNSPECIFIED Hoppe, Sascha UNSPECIFIED https://orcid.org/0000-0001-9246-3747 UNSPECIFIED Simon, Adrian Georg UNSPECIFIED https://orcid.org/0000-0002-2709-863X UNSPECIFIED Zander, Thomas UNSPECIFIED https://orcid.org/0000-0002-4266-6818 UNSPECIFIED Knipper, Karl UNSPECIFIED https://orcid.org/0009-0008-7133-3538 UNSPECIFIED Schroeder, Wolfgang UNSPECIFIED https://orcid.org/0000-0002-8700-069X UNSPECIFIED Bruns, Christiane J. UNSPECIFIED https://orcid.org/0000-0001-6590-8181 UNSPECIFIED Quaas, Alexander UNSPECIFIED https://orcid.org/0000-0002-3537-6011 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-809564
Identification Number:	10.1038/s41598-025-08721-9
Journal or Publication Title:	Scientific Reports
Volume:	15
Number:	1
Page Range:	pp. 1-12
Number of Pages:	12
Date:	9 July 2025
Publisher:	Springer Nature
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie Faculty of Medicine > Innere Medizin > Klinik II für Innere Medizin - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Esophageal adenocarcinoma ; Cytokeratin 5 ; Cytokeratin 6 ; Basal-like subtype ; Poor prognosis English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80956