Universität zu Köln

Ahmed, Momen (2026). Comparative Study of Plasma Osteopontin Levels before and After Knee Joint Replacement Surgery in Patients with Severe Idiopathic Osteoarthritis. PhD thesis, Universität zu Köln.

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Abstract

Osteoarthritis (OA) causes pain, disability, and worse quality of life. Its etiology and pathogenesis are unknown, although OA is widespread. Despite being a cytokine, hormone, and extracellular matrix (ECM) glycoprotein, OPN has been linked to greater cartilage mRNA expression in OA and joint degeneration patients. Method: Thirty patients with endstage osteoarthritic of the knee joints who were scheduled for knee replacement surgery were included. Using an enzyme-linked immunosorbent assay (ELISA), the plasma levels of OP (Osteopontin) were assessed before and six months after the implantation of a total knee replacement. All patients were subjected to full history, clinical examinations and laboratory investigation. Results: Our research included 30 patients, 12 of them were men. The population's mean age was 71.5 years, and their BMI is 29.9. In patients undergoing knee surgery, pre-operative plasma OPN levels varied from 14.3 ng/ml to 241.2 ng/ml with a mean level of 73.4 ng/ml; however, six months after surgery, the mean level increased to 84.9 ng/ml. Conclusion: Plasma OPN levels were examined before and six months after total knee replacement surgery in this study. Even though OPN levels rose up, the difference was not statistically significant. This suggests that surgery may cause complex biological processes that change OPN levels.