Universität zu Köln

Schüller, Thomas ORCID: 0000-0003-1232-7871, Mengotti, Paola ORCID: 0000-0001-8427-1737, Zabicki, Adam, Huys, Daniel ORCID: 0000-0002-9124-4128, Barbe, Michael T. ORCID: 0000-0003-1149-8054, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Vossel, Simone ORCID: 0000-0002-6351-8849 and Baldermann, Juan Carlos ORCID: 0000-0001-5851-9268 (2025). Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome. Brain Communications, 7 (6). pp. 1-11. Oxford University Press. ISSN 2632-1297

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Abstract

[Artikel-Nr.: caf458] People with Tourette syndrome exhibit excessive motor actions known as tics. An aversive sensation called the premonitory urge often precedes these tics, leading to the conceptualization of Tourette syndrome as a sensorimotor disorder. In typical individuals, motor actions adapt flexibly to changes in the predictability of sensory cues. However, it remains unclear whether such sensorimotor predictions are altered in Tourette syndrome and, if so, which neural processes might underlie these changes. This study examined 30 individuals with Tourette syndrome and 30 control participants while recording EEG. Participants performed a motor cueing version of the Posner task, requiring behavioural adjustments to varying levels of cue predictability. Notably, while control participants exhibited the expected interaction between validity and cue predictability on motor responses, this effect was absent in individuals with Tourette syndrome. Neural signatures of flexible predictability-dependent processing were characterized by applying a Bayesian observer model to estimate trial-wise subjective beliefs about cue predictability from response speed and using these model-derived cue predictability estimates in single-trial regression analyses with EEG data. Our findings revealed that model-derived cue predictability modulated P3a amplitude, P3b onset and P3b amplitude differentially. Importantly, P3b amplitude modulations reflected beliefs about cue predictability, which were diminished in participants with Tourette syndrome. Overall, our results indicate that individuals with Tourette syndrome exhibit abnormal behavioural adaptation to the changing predictability of motor cues, suggesting an impaired processing of sensorimotor predictions. At the neural level, this is reflected by impaired activity associated with updating stimulus–response associations.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Schüller, Thomas UNSPECIFIED https://orcid.org/0000-0003-1232-7871 UNSPECIFIED Mengotti, Paola UNSPECIFIED https://orcid.org/0000-0001-8427-1737 UNSPECIFIED Zabicki, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED https://orcid.org/0000-0002-9124-4128 UNSPECIFIED Barbe, Michael T. UNSPECIFIED https://orcid.org/0000-0003-1149-8054 UNSPECIFIED Fink, Gereon R. UNSPECIFIED https://orcid.org/0000-0002-8230-1856 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED https://orcid.org/0000-0002-5274-7929 UNSPECIFIED Vossel, Simone UNSPECIFIED https://orcid.org/0000-0002-6351-8849 UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED https://orcid.org/0000-0001-5851-9268 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811376
Identification Number:	10.1093/braincomms/fcaf458
Journal or Publication Title:	Brain Communications
Volume:	7
Number:	6
Page Range:	pp. 1-11
Number of Pages:	11
Date:	21 November 2025
Publisher:	Oxford University Press
ISSN:	2632-1297
Language:	English
Faculty:	External institution Faculty of Human Sciences Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Human Sciences > Department Psychologie Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Psychosomatik und Psychotherapie > Klinik und Poliklinik für Psychosomatik und Psychotherapie
Subjects:	Psychology Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Tourette syndrome ; P300 ; Bayesian observer model ; motor preparation ; cue predictability English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81137