Universität zu Köln

Gerards, Michelle ORCID: 0009-0001-2294-1181, Baumeister, Annika, Hübner, Constanze, Ribaldi, Federica ORCID: 0000-0001-9208-4472, Cantero-Fortiz, Yahveth ORCID: 0000-0003-0329-6487, Braun, Julia, Boada, Mercè ORCID: 0000-0003-2617-3009, Frisoni, Giovanni B., Jessen, Frank ORCID: 0000-0003-1067-2102, Schmitz-Luhn, Björn ORCID: 0000-0002-3479-6751, Schwegler, Carolin ORCID: 0000-0002-5187-7625, Woopen, Christiane, Rostamzadeh, Ayda ORCID: 0000-0001-5189-134X and Carels, Vanessa (2025). Dementia risk estimation in persons at risk and the predictive turn in Alzheimer’s disease—The PreTAD project: Study protocol with an ethical, clinical, linguistic, and legal approach. PLOS One, 20 (7). pp. 1-19. PLoS Public Library of Science. ISSN 1932-6203

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Abstract

[Artikel-Nr.: e0319868] Background: Despite progress in the field of Alzheimer’s disease (AD) dementia risk estimation, little is known about its impact at the individual and societal levels. Objective: Introducing the explorative tri-national PreTAD project (The Predictive Turn in Alzheimer’s Disease: Ethical, Clinical, Linguistic and Legal Aspects), which aims to (1) learn about attitudes, needs, and perspectives on AD dementia risk estimation of the general population and cognitively unimpaired individuals with and without contact to memory clinics, (2) identify anticipated impacts of AD dementia risk estimation and (3) discuss the implications of the paradigm shift in medicine at individual and societal levels from an ethical, linguistic and legal perspective. Methods: Different approaches are used: (1) an assessment of a population without experience with dementia, (2) an assessment in memory clinics, and (3) an online survey of the general population. Participants include cognitively healthy adults (n=2760), first-degree relatives of dementia patients (n=150), and participants with existing (n=150) and newly diagnosed (n=90) subjective cognitive decline (SCD) from Germany, Switzerland, and Spain. Results: As part of the PreTAD project, new questionnaires are developed that (1) collect attitudes, needs, and perspectives on AD dementia risk estimation and (2) assess anticipated impacts of dementia risk estimation using hypothetical blood-based biomarker dementia risk scenarios. Conclusion: The PreTAD study combines an interdisciplinary approach to develop a framework for predictive medicine in the preclinical stages of AD and supports improving communication of biomarker-based dementia risk estimation in clinical practice. The study was registered in the German Clinical Trials Register (DRKS00029035 on 03/08/2023). Trial registration: German clinical trials register (Deutsches Register Klinischer Studien, DRKS): http://www.drks.de/DRKS00029035 , DRKS registration number: DRKS00029035, date of registration: 08.03.2023. Protocol version 3.0, date 01.06.2024

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Gerards, Michelle UNSPECIFIED https://orcid.org/0009-0001-2294-1181 UNSPECIFIED Baumeister, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Hübner, Constanze UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribaldi, Federica UNSPECIFIED https://orcid.org/0000-0001-9208-4472 UNSPECIFIED Cantero-Fortiz, Yahveth UNSPECIFIED https://orcid.org/0000-0003-0329-6487 UNSPECIFIED Braun, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Boada, Mercè UNSPECIFIED https://orcid.org/0000-0003-2617-3009 UNSPECIFIED Frisoni, Giovanni B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED https://orcid.org/0000-0003-1067-2102 UNSPECIFIED Schmitz-Luhn, Björn UNSPECIFIED https://orcid.org/0000-0002-3479-6751 UNSPECIFIED Schwegler, Carolin UNSPECIFIED https://orcid.org/0000-0002-5187-7625 UNSPECIFIED Woopen, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Rostamzadeh, Ayda UNSPECIFIED https://orcid.org/0000-0001-5189-134X UNSPECIFIED Carels, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811496
Identification Number:	10.1371/journal.pone.0319868
Journal or Publication Title:	PLOS One
Volume:	20
Number:	7
Page Range:	pp. 1-19
Number of Pages:	19
Date:	16 July 2025
Publisher:	PLoS Public Library of Science
ISSN:	1932-6203
Language:	English
Faculty:	Faculty of Arts and Humanities Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Psychiatrie und Psychotherapie > Klinik und Poliklinik für Psychiatrie und Psychotherapie Faculty of Arts and Humanities > Fächergruppe 3: Deutsche Sprache und Literatur > Institut für Deutsche Sprache und Literatur I
Subjects:	Psychology Language, Linguistics Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81149