Universität zu Köln

Dörrenhaus, Robert ORCID: 0009-0006-4685-9939, Wagner, Philip K. and Kath-Schorr, Stephanie ORCID: 0000-0002-5180-360X (2025). Towards a hydrolysis stable artificial base pair with C -glycosides. Chemical Communications, 61 (61). pp. 11481-11484. Royal Society of Chemistry. ISSN 1359-7345

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Abstract

Artificial base-pairs expand the genetic alphabet and allow for site-specific labeling, for example with fluorophores or spin labels, thereby enhancing the capabilities of biomolecular sensing. We developed CTPT3, a stable C -nucleoside pairing with NaM to form a hydrophobic base pair, and demonstrate its enzymatic incorporation into DNA/RNA and facile modification for labeling.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Dörrenhaus, Robert UNSPECIFIED https://orcid.org/0009-0006-4685-9939 UNSPECIFIED Wagner, Philip K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kath-Schorr, Stephanie UNSPECIFIED https://orcid.org/0000-0002-5180-360X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811521
Identification Number:	10.1039/D5CC02749G
Journal or Publication Title:	Chemical Communications
Volume:	61
Number:	61
Page Range:	pp. 11481-11484
Number of Pages:	4
Date:	7 August 2025
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	Life sciences
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81152