Universität zu Köln

Kalbe, Elke, Warnecke, Tobias, Eggers, Carsten, Ophey, Anja ORCID: 0000-0001-5858-7762 and Folkerts, Ann-Kristin ORCID: 0000-0003-2168-140X (2025). Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action. Journal of Parkinson’s Disease, 15 (8). pp. 1353-1366. Sage. ISSN 1877-7171

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Abstract

Mild cognitive impairment and dementia are common symptoms in people with Parkinson’s disease (PwPD) that impair the quality of life of those affected. However, PD-specific concepts for the prevention of cognitive decline are rarely incorporated into routine care. Here, we provide key data on cognitive impairment in PwPD and a frame- work for primary, secondary, and tertiary prevention in this context. The importance of cognitive reserve as a pro- tective buffer for cognitive decline in PwPD is highlighted. Relevant lifestyle and health-related factors, including cognitive aspects, physical and social activity, diet, hearing loss, and cardiovascular factors, are discussed. Evidence on the efficacy of possible cognition-enhancing interventions in PwPD—pharmacological, cognitive, physical, nutri- tional, and multidomain interventions—is summarized. On this basis, and the recommendations of the European Task Force for Brain Health Services, a proposal is developed outlining options for preventing cognitive impairment in PwPD that could be implemented in routine care, as well as further developments needed to achieve a best-case scenario. The main pillars of a strategic agenda for this purpose include: (i) regular assessment of cognitive state, over- all risk, and risk factors for cognitive decline; (ii) risk communication and education concerning modifiable risk factors with standardized procedures; (iii) risk reduction with multi-domain interventions for secondary prevention; and (iv) cognitive enhancement with cognitive and physical training for tertiary prevention. As the proposal makes clear, the prevention of cognitive impairment in PwPD requires interdisciplinary collaboration organized throughout PD care networks.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnecke, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Ophey, Anja UNSPECIFIED https://orcid.org/0000-0001-5858-7762 UNSPECIFIED Folkerts, Ann-Kristin UNSPECIFIED https://orcid.org/0000-0003-2168-140X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811703
Identification Number:	10.1177/1877718X251365769
Journal or Publication Title:	Journal of Parkinson’s Disease
Volume:	15
Number:	8
Page Range:	pp. 1353-1366
Number of Pages:	14
Date:	1 December 2025
Publisher:	Sage
ISSN:	1877-7171
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Medizinische Psychologie > Abteilung für Medizinische Psychologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Parkinson’s disease ; cognition ; dementia ; prevention ; cognitive reserve ; lifestyle English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81170