Universität zu Köln

Hasse, Caroline ORCID: 0000-0001-9757-1843, von Stein, Philipp ORCID: 0000-0003-4548-3897, Althoff, Jan ORCID: 0000-0001-9390-0160, Curio, Jonathan ORCID: 0000-0002-3437-7450, Schäfer, Matthieu ORCID: 0000-0003-1875-1163, Kirchner, Johannes ORCID: 0009-0004-8357-1323, Rudolph, Felix ORCID: 0000-0003-4948-6438, Gietzen, Thorsten ORCID: 0000-0001-7948-202X, von Stein, Jennifer ORCID: 0009-0000-3871-164X, Wrobel, Jan ORCID: 0000-0002-1637-3413, Iliadis, Christos ORCID: 0000-0001-7655-8500, Gerçek, Muhammed, Friedrichs, Kai P., Rudolph, Volker ORCID: 0000-0001-5385-6839, Pfister, Roman ORCID: 0000-0002-4358-5008, Baldus, Stephan ORCID: 0000-0001-8259-1737 and Koerber, Maria I. ORCID: 0000-0001-9073-9279 (2025). Cardiac Remodeling Following Transcatheter Tricuspid Valve Annuloplasty for Tricuspid Regurgitation. JACC: Cardiovascular Interventions, 18 (23). pp. 2911-2921. Elsevier. ISSN 1936-8798

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Abstract

Background: Transcatheter tricuspid valve annuloplasty (TTVA) with the Cardioband has proved to be safe and effective in acutely reducing tricuspid regurgitation (TR). However, long-term outcomes, especially regarding right heart remodeling (RHR), are scarce. Objectives: The aim of this study was to assess long-term efficacy as well as RHR following TTVA. Methods: This retrospective, multicenter study included consecutive patients undergoing TTVA for severe TR at 2 German high-volume centers from 2019 to 2023. Right atrial and right ventricular (RV) parameters and NYHA functional class were assessed at baseline and follow-up. Results: A total of 156 patients were included, and the median time to follow-up was 435 days (Q1-Q3: 156-704 days). TR reduction to ≤2+ was observed in 71% and NYHA functional class improved to ≤II in 68% (P < 0.001 for both). Compared with baseline, right atrial area (36.0 ± 10.1 cm2 vs 30.4 ± 10.7 cm2), RV length (67.5 ± 9.4 mm vs 63.7 ± 9.1 mm), RV midventricular dimension (42.6 ± 8.6 mm vs 35.6 ± 7.8 mm), and RV basal dimension (47.8 ± 6.8 mm vs 42.6 ± 7.5 mm)were significantly reduced at follow-up (P < 0.001 for all). Notably, torrential to severe TR reduction still yielded remodeling (RV basal diameter 50 ± 8.1 mm vs 44 ± 8 mm; P = 0.007). RHR was associated with a decrease in vena contracta width (OR: 1.14; 95% CI: 1.03-1.30; P = 0.015). Conclusions: TTVA is associated with a significant and sustained reduction of TR for more than 1 year. Additionally, patients demonstrated distinct positive cardiac remodeling and functional improvement.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Hasse, Caroline UNSPECIFIED https://orcid.org/0000-0001-9757-1843 UNSPECIFIED von Stein, Philipp UNSPECIFIED https://orcid.org/0000-0003-4548-3897 UNSPECIFIED Althoff, Jan UNSPECIFIED https://orcid.org/0000-0001-9390-0160 UNSPECIFIED Curio, Jonathan UNSPECIFIED https://orcid.org/0000-0002-3437-7450 UNSPECIFIED Schäfer, Matthieu UNSPECIFIED https://orcid.org/0000-0003-1875-1163 UNSPECIFIED Kirchner, Johannes UNSPECIFIED https://orcid.org/0009-0004-8357-1323 UNSPECIFIED Rudolph, Felix UNSPECIFIED https://orcid.org/0000-0003-4948-6438 UNSPECIFIED Gietzen, Thorsten UNSPECIFIED https://orcid.org/0000-0001-7948-202X UNSPECIFIED von Stein, Jennifer UNSPECIFIED https://orcid.org/0009-0000-3871-164X UNSPECIFIED Wrobel, Jan UNSPECIFIED https://orcid.org/0000-0002-1637-3413 UNSPECIFIED Iliadis, Christos UNSPECIFIED https://orcid.org/0000-0001-7655-8500 UNSPECIFIED Gerçek, Muhammed UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrichs, Kai P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Volker UNSPECIFIED https://orcid.org/0000-0001-5385-6839 UNSPECIFIED Pfister, Roman UNSPECIFIED https://orcid.org/0000-0002-4358-5008 UNSPECIFIED Baldus, Stephan UNSPECIFIED https://orcid.org/0000-0001-8259-1737 UNSPECIFIED Koerber, Maria I. UNSPECIFIED https://orcid.org/0000-0001-9073-9279 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812662
Identification Number:	10.1016/j.jcin.2025.10.010
Journal or Publication Title:	JACC: Cardiovascular Interventions
Volume:	18
Number:	23
Page Range:	pp. 2911-2921
Number of Pages:	11
Date:	December 2025
Publisher:	Elsevier
ISSN:	1936-8798
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81266