Universität zu Köln

Kovalyk, Xenia ORCID: 0009-0006-4143-5686, Saniternik, Sven ORCID: 0009-0009-3027-8322, Hamacher, Larissa-M. ORCID: 0009-0004-9382-5251, Mink, Ben Lasse, Thoröe-Boveleth, Sven, Bach, Patricia ORCID: 0009-0002-4372-1791, Endres, Thomas, Montero-Mirabet, Maria, Schmidt, Annette M. ORCID: 0000-0002-7284-7847 and Grüll, Holger ORCID: 0000-0002-0993-9300 (2026). Gelatin and collagen-mimetic nanoparticles for intraperitoneal cisplatin delivery: From synthesis to in-vivo SPECT imaging of biodistribution. Biomaterials Advances, 180. pp. 1-12. Elsevier. ISSN 2772-9508

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Abstract

[Artikel-Nr.: 214601] Peritoneal carcinomatosis is a metastatic condition with poor prognosis, commonly associated with abdominal cancers. Current treatments comprise cytoreductive surgery with systemic chemotherapy or may include more invasive options such as hyperthermic intraperitoneal chemotherapy, and pressurized intraperitoneal aerosol chemotherapy. However, currently, all treatment options are considered palliative as remaining cancer cells cause recurrence. This study explores new intraperitoneal drug delivery systems based on gelatin-poly(glutamic acid) (Gel-PGA-NPs) or collagen-like-peptide-poly(glutamic acid) nanoparticles (CLP-PGA-NPs) loaded with cisplatin for localized treatment of peritoneal carcinomatosis. These NPs, synthesized via in situ polymerization, offer prolonged drug release and continuous biodegradation. The used CLP is produced by a recombinant manufacturing method avoiding any animal-derived material, which has advantages in regard to biocompatibility and reproducibility. Characterization by dynamic light scattering and transmission electron microscopy showed NPs averaging 150 nm in size. Cisplatin loading in CLP-PGA NPs facilitated high drug loading and stability compared to Gel-PGA NPs. SPECT/CT imaging of radiolabeled NPs in healthy mice revealed primary uptake in the spleen and liver, and further accumulation in the pancreas, ovaries and adherence to abdominal tissues highlighting the potential use for treatment of intraperitoneal metastases.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kovalyk, Xenia UNSPECIFIED https://orcid.org/0009-0006-4143-5686 UNSPECIFIED Saniternik, Sven UNSPECIFIED https://orcid.org/0009-0009-3027-8322 UNSPECIFIED Hamacher, Larissa-M. UNSPECIFIED https://orcid.org/0009-0004-9382-5251 UNSPECIFIED Mink, Ben Lasse UNSPECIFIED UNSPECIFIED UNSPECIFIED Thoröe-Boveleth, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Bach, Patricia UNSPECIFIED https://orcid.org/0009-0002-4372-1791 UNSPECIFIED Endres, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Montero-Mirabet, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Annette M. UNSPECIFIED https://orcid.org/0000-0002-7284-7847 UNSPECIFIED Grüll, Holger UNSPECIFIED https://orcid.org/0000-0002-0993-9300 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812741
Identification Number:	10.1016/j.bioadv.2025.214601
Journal or Publication Title:	Biomaterials Advances
Volume:	180
Page Range:	pp. 1-12
Number of Pages:	12
Date:	March 2026
Publisher:	Elsevier
ISSN:	2772-9508
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences Faculty of Medicine
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry Faculty of Medicine > Experimentelle Medizin > Institut für Experimentelle Medizin Faculty of Medicine > Radiologische Diagnostik > Institut und Poliklinik für Radiologische Diagnostik
Subjects:	Chemistry and allied sciences Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81274