Universität zu Köln

Többen, Christina ORCID: 0000-0003-1185-1583, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Joisten, Carolin S. ORCID: 0000-0001-8615-9730, Sal, Ertan ORCID: 0000-0003-2761-2675, Cozzi, José A., Hoellinger, Baptiste ORCID: 0000-0002-2570-4763, Karapinar, Deniz Yilmaz ORCID: 0000-0002-1637-4678, Richter, Daniel, Groll, Andreas H. ORCID: 0000-0003-1188-393X, Méndez, Gustavo-Adolfo ORCID: 0000-0003-0514-7004, Jenks, Jeffrey D. ORCID: 0000-0001-6632-9587, Erben, Nurettin ORCID: 0000-0003-0373-0132, Soria, Leyre López ORCID: 0000-0003-2335-8665, Koehler, Philipp ORCID: 0000-0002-7386-7495, Apostolopoulou, Anna ORCID: 0000-0002-8874-0980, Deeren, Dries ORCID: 0000-0001-9599-2142, Draenert, Rika ORCID: 0000-0001-6049-3626, Falces-Romero, Iker ORCID: 0000-0001-5888-7706, Maquera-Afaray, Julio ORCID: 0000-0002-3698-8343, Meintker, Lisa ORCID: 0000-0002-0548-8127, Kolamunnage-Dona, Ruwanthi ORCID: 0000-0003-3886-6208, Seidel, Danila ORCID: 0000-0003-4388-3117 and Stemler, Jannik ORCID: 0000-0001-9152-2469 (2026). Sequential serum galactomannan as outcome marker for invasive aspergillosis—An exploratory study from the FungiScope registry. International Journal of Infectious Diseases, 163. pp. 1-7. Elsevier. ISSN 1201-9712

PDF 1-s2.0-S1201971225004941-main.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (1MB)

Abstract

[Artikel-Nr.: 108272] Background: Galactomannan index (GMI) is established as a diagnostic tool for invasive aspergillosis (IA), while its utility in monitoring antifungal treatment (AFT) response and prognostic value remains unclear. This study evaluated the validity of serum GM as a biomarker for AFT monitoring and its prognostic significance by correlating GMI with clinical response and survival of IA. Objectives: Patients with IA and at least two sequential serum GMI measurements were identified from the FungiScope registry. Joint models of event-time and longitudinal outcome were used for imputing missing GMI to account for the relationship between GMI and time to death, as well as GMI and time to drop-out for the survival analysis and AFT response analysis, respectively. Cox proportional hazards models and logistic regression models assessed survival and clinical response on GMI changes at day 7, with baseline log GMI as an adjustment covariate.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Többen, Christina UNSPECIFIED https://orcid.org/0000-0003-1185-1583 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Joisten, Carolin S. UNSPECIFIED https://orcid.org/0000-0001-8615-9730 UNSPECIFIED Sal, Ertan UNSPECIFIED https://orcid.org/0000-0003-2761-2675 UNSPECIFIED Cozzi, José A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoellinger, Baptiste UNSPECIFIED https://orcid.org/0000-0002-2570-4763 UNSPECIFIED Karapinar, Deniz Yilmaz UNSPECIFIED https://orcid.org/0000-0002-1637-4678 UNSPECIFIED Richter, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Groll, Andreas H. UNSPECIFIED https://orcid.org/0000-0003-1188-393X UNSPECIFIED Méndez, Gustavo-Adolfo UNSPECIFIED https://orcid.org/0000-0003-0514-7004 UNSPECIFIED Jenks, Jeffrey D. UNSPECIFIED https://orcid.org/0000-0001-6632-9587 UNSPECIFIED Erben, Nurettin UNSPECIFIED https://orcid.org/0000-0003-0373-0132 UNSPECIFIED Soria, Leyre López UNSPECIFIED https://orcid.org/0000-0003-2335-8665 UNSPECIFIED Koehler, Philipp UNSPECIFIED https://orcid.org/0000-0002-7386-7495 UNSPECIFIED Apostolopoulou, Anna UNSPECIFIED https://orcid.org/0000-0002-8874-0980 UNSPECIFIED Deeren, Dries UNSPECIFIED https://orcid.org/0000-0001-9599-2142 UNSPECIFIED Draenert, Rika UNSPECIFIED https://orcid.org/0000-0001-6049-3626 UNSPECIFIED Falces-Romero, Iker UNSPECIFIED https://orcid.org/0000-0001-5888-7706 UNSPECIFIED Maquera-Afaray, Julio UNSPECIFIED https://orcid.org/0000-0002-3698-8343 UNSPECIFIED Meintker, Lisa UNSPECIFIED https://orcid.org/0000-0002-0548-8127 UNSPECIFIED Kolamunnage-Dona, Ruwanthi UNSPECIFIED https://orcid.org/0000-0003-3886-6208 UNSPECIFIED Seidel, Danila UNSPECIFIED https://orcid.org/0000-0003-4388-3117 UNSPECIFIED Stemler, Jannik UNSPECIFIED https://orcid.org/0000-0001-9152-2469 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812785
Identification Number:	10.1016/j.ijid.2025.108272
Journal or Publication Title:	International Journal of Infectious Diseases
Volume:	163
Page Range:	pp. 1-7
Number of Pages:	7
Date:	February 2026
Publisher:	Elsevier
ISSN:	1201-9712
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Biomarker ; Immunocompromised host ; Treatment monitoring ; Registry study ; Invasive aspergillosis ; Galactomannan assay English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81278