Blaschke, Stefan J. 
ORCID: 0000-0001-8643-3824, Backes, Heiko ORCID: 0000-0002-0318-1615, Vlachakis, Susan ORCID: 0000-0002-9429-2475, Rautenberg, Nora ORCID: 0009-0008-6094-3082, Demir, Seda ORCID: 0000-0002-4569-4996, Wiedermann, Dirk, Aswendt, Markus, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Schroeter, Michael ORCID: 0000-0001-8441-4793 and Rueger, Maria A. ORCID: 0000-0001-8036-395X
(2026).
Subacute cathodal transcranial direct current stimulation rescues secondary thalamic neurodegeneration after cortical stroke in mice.
Experimental Neurology, 398.
pp. 1-11.
Elsevier.
ISSN 0014-4886
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Abstract
[Artikel-Nr.: 115604] Transcranial direct current stimulation (tDCS) is a clinically promising neuromodulatory therapy, capable of promoting function and motor recovery after stroke. Beyond the primary stroke lesion, remote networks disturbances, e.g., stroke-induced secondary neurodegeneration (SND), are related to long-term disabilities. Under the hypothesis that tDCS promotes recovery by supporting neuroprotection, we investigated the effects of tDCS on thalamic SND after stroke. Three days after cortical stroke, induced by photothrombosis, cathodal tDCS over the lesioned cortex was performed daily for ten days (39.6 kC/m2). SND, i.e., neuronal loss, and inflammation in the ipsilesional thalamus were evaluated ex vivo 28 days after stroke. Parameters of functional thalamic network integration measured by resting-state functional magnetic resonance imaging (rs-fMRI) were conducted longitudinally. To assess the effects of tDCS on glucose metabolism, positron emission tomography (PET) was performed after a similar tDCS regimen in healthy mice. Repetitive tDCS decreased the ipsilateral thalamic glucose metabolism in unlesioned animals. Four weeks after cortical stroke, secondary glial scaring was found in the ipsilesional thalamus, its extent correlating to the cortical lesion size (R2 = 0.54, p < 0.001). Notably, while it did not affect glial scaring, tDCS reduced thalamic neurodegeneration by over 60 % (p < 0.05), being reflected by parameters of functional thalamic integration as assessed by rs-fMRI. Additionally, tDCS downregulated the pro-inflammatory polarization of microglia. Overall, tDCS ameliorated the stroke-induced remote SND, in parallel to mitigating sustained neuroinflammation. Thus, the data show that tDCS exerts previously unknown effects on remote brain regions after stroke.
| Item Type: | Article |
| Creators: | Creators Email ORCID ORCID Put Code Wiedermann, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Aswendt, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED |
| URN: | urn:nbn:de:hbz:38-812850 |
| Identification Number: | 10.1016/j.expneurol.2025.115604 |
| Journal or Publication Title: | Experimental Neurology |
| Volume: | 398 |
| Page Range: | pp. 1-11 |
| Number of Pages: | 11 |
| Date: | April 2026 |
| Publisher: | Elsevier |
| ISSN: | 0014-4886 |
| Language: | English |
| Faculty: | External institution Faculty of Medicine |
| Divisions: | Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Außeruniversitäre Forschungseinrichtungen > MPI for Metabolism Research Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie |
| Subjects: | Medical sciences Medicine |
| Uncontrolled Keywords: | Keywords Language Experimental stroke ; Transcranial direct current stimulation ; Stroke recovery ; Secondary neurodegeneration ; Neuroinflammation ; Glucose metabolism English |
| ['eprint_fieldname_oa_funders' not defined]: | Publikationsfonds UzK |
| Refereed: | Yes |
| URI: | http://kups.ub.uni-koeln.de/id/eprint/81285 |
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