Universität zu Köln

Jansen, Louis ORCID: 0000-0003-0332-1099, Mayer, Marcel ORCID: 0000-0001-9963-1109, Stang, Andreas, Kajueter, Hiltraud, Oesterling, Florian ORCID: 0000-0002-5840-8274, Szentkiralyi, Andras ORCID: 0000-0002-7892-2422, Kourou, Sofia ORCID: 0009-0000-2277-4160, Wolber, Philipp ORCID: 0000-0001-9019-2840, van de Loo, Julia, Hieggelke, Lena ORCID: 0000-0002-1831-0387, Quaas, Alexander ORCID: 0000-0002-3537-6011, Klussmann, Jens Peter ORCID: 0000-0002-8223-7954 and Nachtsheim, Lisa ORCID: 0000-0002-0261-4511 (2026). Incidence and survival of primary major salivary gland carcinoma in Germany over the last decade: A nationwide population-based study. European Journal of Cancer, 234. pp. 1-8. Elsevier. ISSN 0959-8049

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Abstract

[Artikel-Nr.: 116196] Background: Primary salivary gland carcinomas (SGC) are rare tumors comprising 5 % of head and neck cancers. While most published studies on SGC in Germany focus on state-level data, nationwide population-based data on incidence, demographics, and outcomes have not been reported. Objectives: This study aimed to provide a nationwide overview of the incidence, clinicopathologic characteristics, and survival of patients with primary SGC of the major salivary glands in Germany. Design and methods: Data were extracted from the German Centre for Cancer Registry Data (ZfKD), covering all 16 federal states, for the period 2009–2022. Patients with primary malignant neoplasms of the major salivary glands were included. Crude and age standardized incidence rates were calculated. Relative survival was estimated using the period approach, stratified by demographic and tumor characteristics. Results: We identified 10,808 SGC cases. The most frequent subtypes were adenocarcinoma not otherwise specified (ANOS) (18.4 %), mucoepidermoid (MEC, 13.5 %), adenoid cystic (ACC, 13.3 %), acinic cell (Acin, 10.4 %), and salivary duct carcinoma (SDC, 5.7 %). The mean age-standardized incidence rate was 5.2/1000,000 person-years, 5.8 for men and 4.8 for women, and increased slightly over observation period. A decline in ANOS and increase in SDC incidence were observed, primarily among men. The five-year relative survival was 70 %, with a pronounced disparity observed between male (62 %) and female (80 %) patients. Survival declined with advanced tumor status, nodal involvement, and distant metastasis. Conclusion: To date, this represents the largest epidemiological investigation of major SGC worldwide. Over the observation period, the incidence of major SGC has slightly increased in Germany. Men showed a distinctly more unfavorable prognosis than women and were more likely to be diagnosed with aggressive entities like ANOS and SDC.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Jansen, Louis UNSPECIFIED https://orcid.org/0000-0003-0332-1099 UNSPECIFIED Mayer, Marcel UNSPECIFIED https://orcid.org/0000-0001-9963-1109 UNSPECIFIED Stang, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kajueter, Hiltraud UNSPECIFIED UNSPECIFIED UNSPECIFIED Oesterling, Florian UNSPECIFIED https://orcid.org/0000-0002-5840-8274 UNSPECIFIED Szentkiralyi, Andras UNSPECIFIED https://orcid.org/0000-0002-7892-2422 UNSPECIFIED Kourou, Sofia UNSPECIFIED https://orcid.org/0009-0000-2277-4160 UNSPECIFIED Wolber, Philipp UNSPECIFIED https://orcid.org/0000-0001-9019-2840 UNSPECIFIED van de Loo, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hieggelke, Lena UNSPECIFIED https://orcid.org/0000-0002-1831-0387 UNSPECIFIED Quaas, Alexander UNSPECIFIED https://orcid.org/0000-0002-3537-6011 UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED https://orcid.org/0000-0002-8223-7954 UNSPECIFIED Nachtsheim, Lisa UNSPECIFIED https://orcid.org/0000-0002-0261-4511 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812875
Identification Number:	10.1016/j.ejca.2025.116196
Journal or Publication Title:	European Journal of Cancer
Volume:	234
Page Range:	pp. 1-8
Number of Pages:	8
Date:	5 February 2026
Publisher:	Elsevier
ISSN:	0959-8049
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Hals-Nasen-Ohrenheilkunde > Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Salivary gland cancer ; Cancer epidemiology ; Public health ; Population-based cancer research ; Head and neck oncology English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81287