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Seidel, Danila ORCID: 0000-0003-4388-3117, Pana, Zoi Dorothea ORCID: 0000-0002-5893-1081, Ebrahimi‐Fakhari, Daniel ORCID: 0000-0002-3097-141X, Butzer, Sarina K. ORCID: 0000-0002-4812-9220, Mehler, Katrin ORCID: 0000-0002-3052-2147, Reinhold, Ilana ORCID: 0000-0002-6222-0418, Simon, Arne ORCID: 0000-0001-9558-3330, Dohna‐Schwake, Christian, Mack, Ines ORCID: 0000-0002-6648-7996, Bodmer, Nicole, Niehues, Tim, Claviez, Alexander ORCID: 0000-0001-7064-8556, Längler, Alfred ORCID: 0000-0002-1443-8236, Leipold, Alfred, Prokop, Aram, Brummel, Bastian, Winkler, Beate, Gruhn, Bernd ORCID: 0000-0003-1862-0075, Classen, Carl Friedrich, Friedrich, Carsten, Koenig, Christa, Flotho, Christian, Poyer, Fiona ORCID: 0000-0002-3393-9706, Schilling, Freimut, Calaminus, Gabriele, Sieben, Geeke, Schwabe, Georg C. ORCID: 0000-0003-4299-3410, Reinhard, Harald, Teltschik, Heiko‐Manuel, Hengartner, Heinz, Stursberg, Jana, Greiner, Jeanette, Greil, Johann ORCID: 0000-0003-1821-1183, Leyh, Jörg, Kühl, Jörn‐Sven, Ehlert, Karoline, Bochennek, Konrad, Rohde, Marius ORCID: 0000-0002-1487-525X, Demmert, Martin ORCID: 0000-0001-7552-3736, Stiefel, Martina ORCID: 0009-0002-3277-7212, Eyrich, Matthias, Siepermann, Meinolf, Frühwald, Michael ORCID: 0000-0002-8237-1854, Döring, Michaela ORCID: 0000-0002-8134-7350, Nathrath, Michaela ORCID: 0000-0002-1584-1115, Minkov, Milen ORCID: 0000-0001-6471-8423, Streiter, Monika, Jones, Neil, Naumann‐Bartsch, Nora ORCID: 0000-0001-5606-9822, Jorch, Norbert, Beck, Olaf ORCID: 0000-0002-7448-6029, Beier, Rita, Crazzolara, Roman ORCID: 0000-0003-4336-6275, Kietz, Silke, Vieth, Simon, Fröhling, Stefan, Lobitz, Stephan ORCID: 0000-0001-5398-0610, Ghosh, Sujal ORCID: 0000-0001-5647-4262, Vallée, Tanja C. ORCID: 0009-0003-0171-1146, Müller, Thilo, Wiesel, Thomas, Däbritz, Tobias, Kontny, Udo, Thiel, Uwe ORCID: 0000-0002-3574-7337, Strenger, Volker ORCID: 0000-0002-6947-5894, Eberl, Wolfgang R., Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Groll, Andreas H. ORCID: 0000-0003-1188-393X and Lehrnbecher, Thomas ORCID: 0000-0002-6022-3439 (2025). Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland. Mycoses, 68 (6). pp. 1-14. Wiley. ISSN 0933-7407

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Abstract

[Artikel-Nr.: e70074] Background: Invasive fungal diseases (IFD) pose significant challenges in paediatric oncology. Their management is compli- cated by limited paediatric-specific evidence, lack of standardised protocols and variability in resources across centres. This study assessed current practices and addressed the challenges in the prevention, diagnosis and treatment of IFDs in paediatric oncology centres across Germany, Austria and Switzerland. Methods: A questionnaire was distributed to senior paediatric oncologists in 70 paediatric oncology centres across Germany, Austria and Switzerland, gathering data on centre infrastructure, infectious disease (ID) expertise, annual cumulative IFD in- cidence in 2023, diagnostic tools, antifungal prophylaxis, treatment and follow-up practices for IFD. Responses were analysed descriptively. Results: Sixty-two centres responded, with a median of 56 (IQR 40–75) new oncological diagnoses per centre; 54.8% of centres managed allogeneic HCT patients. IFDs were reported in 88.7% of centres, with a median cumulative IFD incidence of 4.6% (IQR 3.0%–5.9%). No significant association was found between cumulative IFD incidence and the number of transplants, antifungal prophylaxis protocols and availability of ID consultation services. ID consultation was available in 58.1% of centres, with 24/7 support provided in 41.7% of these centres. Larger centres more frequently had paediatric ID specialists, ID consultation services and access to therapeutic drug monitoring. Conclusions: The observed heterogeneity in mycology expertise and IFD management strategies across centres reflects the inherent complexity of IFDs and the diagnostic and therapeutic uncertainties amid limited evidence. Strengthening oncology-ID.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Seidel, Danila UNSPECIFIED https://orcid.org/0000-0003-4388-3117 UNSPECIFIED Pana, Zoi Dorothea UNSPECIFIED https://orcid.org/0000-0002-5893-1081 UNSPECIFIED Ebrahimi‐Fakhari, Daniel UNSPECIFIED https://orcid.org/0000-0002-3097-141X UNSPECIFIED Butzer, Sarina K. UNSPECIFIED https://orcid.org/0000-0002-4812-9220 UNSPECIFIED Mehler, Katrin UNSPECIFIED https://orcid.org/0000-0002-3052-2147 UNSPECIFIED Reinhold, Ilana UNSPECIFIED https://orcid.org/0000-0002-6222-0418 UNSPECIFIED Simon, Arne UNSPECIFIED https://orcid.org/0000-0001-9558-3330 UNSPECIFIED Dohna‐Schwake, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mack, Ines UNSPECIFIED https://orcid.org/0000-0002-6648-7996 UNSPECIFIED Bodmer, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehues, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Claviez, Alexander UNSPECIFIED https://orcid.org/0000-0001-7064-8556 UNSPECIFIED Längler, Alfred UNSPECIFIED https://orcid.org/0000-0002-1443-8236 UNSPECIFIED Leipold, Alfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED Brummel, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Winkler, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruhn, Bernd UNSPECIFIED https://orcid.org/0000-0003-1862-0075 UNSPECIFIED Classen, Carl Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrich, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Christa UNSPECIFIED UNSPECIFIED UNSPECIFIED Flotho, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Poyer, Fiona UNSPECIFIED https://orcid.org/0000-0002-3393-9706 UNSPECIFIED Schilling, Freimut UNSPECIFIED UNSPECIFIED UNSPECIFIED Calaminus, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Sieben, Geeke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwabe, Georg C. UNSPECIFIED https://orcid.org/0000-0003-4299-3410 UNSPECIFIED Reinhard, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Teltschik, Heiko‐Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hengartner, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Stursberg, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Greiner, Jeanette UNSPECIFIED UNSPECIFIED UNSPECIFIED Greil, Johann UNSPECIFIED https://orcid.org/0000-0003-1821-1183 UNSPECIFIED Leyh, Jörg UNSPECIFIED UNSPECIFIED UNSPECIFIED Kühl, Jörn‐Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehlert, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Bochennek, Konrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohde, Marius UNSPECIFIED https://orcid.org/0000-0002-1487-525X UNSPECIFIED Demmert, Martin UNSPECIFIED https://orcid.org/0000-0001-7552-3736 UNSPECIFIED Stiefel, Martina UNSPECIFIED https://orcid.org/0009-0002-3277-7212 UNSPECIFIED Eyrich, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Siepermann, Meinolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Frühwald, Michael UNSPECIFIED https://orcid.org/0000-0002-8237-1854 UNSPECIFIED Döring, Michaela UNSPECIFIED https://orcid.org/0000-0002-8134-7350 UNSPECIFIED Nathrath, Michaela UNSPECIFIED https://orcid.org/0000-0002-1584-1115 UNSPECIFIED Minkov, Milen UNSPECIFIED https://orcid.org/0000-0001-6471-8423 UNSPECIFIED Streiter, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Jones, Neil UNSPECIFIED UNSPECIFIED UNSPECIFIED Naumann‐Bartsch, Nora UNSPECIFIED https://orcid.org/0000-0001-5606-9822 UNSPECIFIED Jorch, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Beck, Olaf UNSPECIFIED https://orcid.org/0000-0002-7448-6029 UNSPECIFIED Beier, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Crazzolara, Roman UNSPECIFIED https://orcid.org/0000-0003-4336-6275 UNSPECIFIED Kietz, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieth, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Fröhling, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lobitz, Stephan UNSPECIFIED https://orcid.org/0000-0001-5398-0610 UNSPECIFIED Ghosh, Sujal UNSPECIFIED https://orcid.org/0000-0001-5647-4262 UNSPECIFIED Vallée, Tanja C. UNSPECIFIED https://orcid.org/0009-0003-0171-1146 UNSPECIFIED Müller, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiesel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Däbritz, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kontny, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiel, Uwe UNSPECIFIED https://orcid.org/0000-0002-3574-7337 UNSPECIFIED Strenger, Volker UNSPECIFIED https://orcid.org/0000-0002-6947-5894 UNSPECIFIED Eberl, Wolfgang R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Groll, Andreas H. UNSPECIFIED https://orcid.org/0000-0003-1188-393X UNSPECIFIED Lehrnbecher, Thomas UNSPECIFIED https://orcid.org/0000-0002-6022-3439 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812908
Identification Number:	10.1111/myc.70074
Journal or Publication Title:	Mycoses
Volume:	68
Number:	6
Page Range:	pp. 1-14
Number of Pages:	14
Date:	14 June 2025
Publisher:	Wiley
ISSN:	0933-7407
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language antifungal stewardship ; aspergillosis ; cancer ; candidaemia ; children ; diagnosis ; management ; mycoses ; prophylaxis ; treatment English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81290