Universität zu Köln

Reinhold, Ilana ORCID: 0000-0002-6222-0418, Mori, Giovanni ORCID: 0000-0003-0399-2220, Lanzafame, Massimiliano ORCID: 0000-0002-4674-4772, Limongelli, Alessandro ORCID: 0000-0001-7995-5528, Vena, Antonio ORCID: 0000-0002-0697-3992, Götz, Julia ORCID: 0009-0003-5003-7821, Bauernfeind, Stilla, Hanses, Frank ORCID: 0000-0002-0007-8014, Tometten, Lukas ORCID: 0000-0002-5968-8335, Mayer, Michael, Rieke, Ansgar, Soriano‐Martin, Ana ORCID: 0000-0002-7226-8212, Valerio, Maricela ORCID: 0000-0001-6394-2861, Vazquez, Jose A. ORCID: 0000-0001-5774-819X, Yue, Patrick, Rahimli, Laman ORCID: 0000-0003-2266-445X, Azimli, Nijat ORCID: 0009-0000-8897-9417, Sal, Ertan ORCID: 0000-0003-2761-2675, Salmanton‐García, Jon ORCID: 0000-0002-6766-8297, Vasenda, Natalia ORCID: 0000-0002-8606-3621, Sprute, Rosanne ORCID: 0000-0003-2457-6437, Stemler, Jannik ORCID: 0000-0001-9152-2469, Wingen‐Heimann, Sebastian ORCID: 0000-0002-4232-6944, Cornely, Oliver A. ORCID: 0000-0001-9599-3137 and Seidel, Danila ORCID: 0000-0003-4388-3117 (2025). Rezafungin Utilisation in Real Life— FungiScope Results From Europe and the United States. Mycoses, 68 (9). pp. 1-16. Wiley. ISSN 0933-7407

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Abstract

[Artikel-Nr.: e70114] Background: Rezafungin, a novel echinocandin with once-weekly intravenous dosing, offers potential advantages for outpa- tient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy and safety, real-world experience remains limited. Methods: A retrospective analysis of patients treated with rezafungin across Germany, Italy, Spain, and the United States be- tween January 2024 and June 2025 was conducted. Data was collected via the FungiScope registry. Clinical characteristics, indications for rezafungin, outcomes, safety, and logistical aspects of administration were evaluated. Results: Fifteen patients were included, fourteen with IC; one with chronic pulmonary aspergillosis. Regarding patients with IC, the median age was 65.5 years; 43% were female. The most frequently identified pathogens were Candida glabrata (57%) and Candida parapsilosis (21%). Primary indications for rezafungin were intravascular (36%) and osteoarticular infections (36%). Rezafungin was mainly selected to enable OPAT (86%) or due to fluconazole resistance (36%) or drug–drug interactions (14%). The median treatment duration was 9 weeks (range: 1–38 weeks). One mild adverse event occurred (cutaneous photosensitivity), but rezafungin was otherwise well tolerated. Complete clinical or mycological response was observed in 36% at day 30, and partial response in 50% of patients. Access differed substantially across centres due to administrative and reimbursement hur- dles, affecting treatment transition to rezafungin in 71% of patients with IC. Conclusions: Rezafungin was effective and well tolerated in this cohort, particularly in patients requiring long-term treatment. Administrative and logistical hurdles remain significant barriers to its widespread use. Facilitated access and enhanced aware- ness may improve patient outcomes by supporting early initiation and continuity of care.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Reinhold, Ilana UNSPECIFIED https://orcid.org/0000-0002-6222-0418 UNSPECIFIED Mori, Giovanni UNSPECIFIED https://orcid.org/0000-0003-0399-2220 UNSPECIFIED Lanzafame, Massimiliano UNSPECIFIED https://orcid.org/0000-0002-4674-4772 UNSPECIFIED Limongelli, Alessandro UNSPECIFIED https://orcid.org/0000-0001-7995-5528 UNSPECIFIED Vena, Antonio UNSPECIFIED https://orcid.org/0000-0002-0697-3992 UNSPECIFIED Götz, Julia UNSPECIFIED https://orcid.org/0009-0003-5003-7821 UNSPECIFIED Bauernfeind, Stilla UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanses, Frank UNSPECIFIED https://orcid.org/0000-0002-0007-8014 UNSPECIFIED Tometten, Lukas UNSPECIFIED https://orcid.org/0000-0002-5968-8335 UNSPECIFIED Mayer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieke, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Soriano‐Martin, Ana UNSPECIFIED https://orcid.org/0000-0002-7226-8212 UNSPECIFIED Valerio, Maricela UNSPECIFIED https://orcid.org/0000-0001-6394-2861 UNSPECIFIED Vazquez, Jose A. UNSPECIFIED https://orcid.org/0000-0001-5774-819X UNSPECIFIED Yue, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahimli, Laman UNSPECIFIED https://orcid.org/0000-0003-2266-445X UNSPECIFIED Azimli, Nijat UNSPECIFIED https://orcid.org/0009-0000-8897-9417 UNSPECIFIED Sal, Ertan UNSPECIFIED https://orcid.org/0000-0003-2761-2675 UNSPECIFIED Salmanton‐García, Jon UNSPECIFIED https://orcid.org/0000-0002-6766-8297 UNSPECIFIED Vasenda, Natalia UNSPECIFIED https://orcid.org/0000-0002-8606-3621 UNSPECIFIED Sprute, Rosanne UNSPECIFIED https://orcid.org/0000-0003-2457-6437 UNSPECIFIED Stemler, Jannik UNSPECIFIED https://orcid.org/0000-0001-9152-2469 UNSPECIFIED Wingen‐Heimann, Sebastian UNSPECIFIED https://orcid.org/0000-0002-4232-6944 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Seidel, Danila UNSPECIFIED https://orcid.org/0000-0003-4388-3117 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812922
Identification Number:	10.1111/myc.70114
Journal or Publication Title:	Mycoses
Volume:	68
Number:	9
Page Range:	pp. 1-16
Number of Pages:	16
Date:	17 September 2025
Publisher:	Wiley
ISSN:	0933-7407
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO) Faculty of Medicine > Weitere > Zentrum für Klinische Studien
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language antifungal treatment ; candidemia ; chronic pulmonary aspergillosis ; invasive candidiasis English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81292