Universität zu Köln

Taylan, Christina ORCID: 0000-0001-9585-054X, Mückenhausen, Sabine I., Weber, Lutz T. ORCID: 0000-0003-4116-598X, Stippel, Dirk L. ORCID: 0000-0002-1107-0907 and Thumfart, Julia ORCID: 0000-0003-1162-5295 (2026). Midterm Outcome of AB0 Incompatible Kidney Transplantation in Children and Adolescents—A Single Center Experience. Pediatric Transplantation, 30 (1). pp. 1-9. Wiley. ISSN 1397-3142

PDF Pediatric Transplantation - 2026 - Taylan - Midterm Outcome of AB0 Incompatible Kidney Transplantation in Children and.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (319kB)

Abstract

[Artikel-Nr.: :e70248] Background: In order to reduce the waiting time, new strategies have been developed to safely transplant donor and recipient pairs with mismatched blood groups. The present study examined the safety of the preparatory treatments and the midterm outcom of AB0 incompatible (AB0i) kidney transplantation in children. Methods: We retrospectively analyzed 10 children who received a kidney transplant from an AB0i donor from 2012 to 2024 and 30 patients matched by sex, height, and weight who received an AB0 compatible (AB0c) living kidney transplant in the same period. Results: In the AB0i group, preparatory treatment before KTx was well tolerated. The number of rejection episodes was comparable in the AB0i group and in the AB0c group (three episodes in three patients vs. seven episodes in six patients) during the observation period of 36 months, with rejections occurring earlier in the AB0c group. Infections were more frequent in the AB0c group than in the AB0i group (30 episodes in 23 patients [76%] vs. eight episodes in six patients [60%]). In the AB0i group, the 3-year graft survival rate was 90%; the 3-year patient survival was 100%. In the AB0c group, the 3-year graft survival was 86.8%, and the 3-year patient survival was 93.3%. There was no difference in graft survival (p = 0.08) and patient survival (p = 0.24) between the AB0i and AB0c groups. Conclusions: AB0 incompatible kidney transplants can be safely performed in children with equivalent midterm graft and patient survival.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Taylan, Christina UNSPECIFIED https://orcid.org/0000-0001-9585-054X UNSPECIFIED Mückenhausen, Sabine I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Lutz T. UNSPECIFIED https://orcid.org/0000-0003-4116-598X UNSPECIFIED Stippel, Dirk L. UNSPECIFIED https://orcid.org/0000-0002-1107-0907 UNSPECIFIED Thumfart, Julia UNSPECIFIED https://orcid.org/0000-0003-1162-5295 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812962
Identification Number:	10.1111/petr.70248
Journal or Publication Title:	Pediatric Transplantation
Volume:	30
Number:	1
Page Range:	pp. 1-9
Number of Pages:	9
Date:	22 January 2026
Publisher:	Wiley
ISSN:	1397-3142
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language graft loss ; immunoadsorption ; kidney transplant ; plasma exchange English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81296