Universität zu Köln

Loução, Ricardo ORCID: 0000-0002-0310-0352, Burkhardt, Julia, Wirths, Jochen, Kabbasch, Christoph ORCID: 0000-0003-3712-2258, Dembek, Till A. ORCID: 0000-0001-7023-146X, Heiden, Petra ORCID: 0000-0001-7295-5437, Cirak, Sebahattin ORCID: 0009-0001-1011-2618, Al-Fatly, Bassam ORCID: 0000-0003-0067-6177, Treuer, Harald, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Hoevels, Mauritius and Koy, Anne ORCID: 0000-0002-7991-4432 (2024). Diffusion tensor imaging in pediatric patients with dystonia. NeuroImage, 287. pp. 1-9. Elsevier. ISSN 1053-8119

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Abstract

[Artikel-Nr. 120507] Background: Childhood-onset dystonia is often progressive and severely impairs a child´s life. The pathophysiology is very heterogeneous and treatment responses vary in patients with dystonia. Factors influencing treatment effects remain to be elucidated. We hypothesize that differences in brain connectivity and fiber coherence contribute to the heterogeneity in treatment response among pediatric patients with inherited and acquired dystonia. Methods: Twenty patients with childhood-onset dystonia were retrospectively recruited including twelve patients with inherited or idiopathic, and eight patients with acquired dystonia (mean age 10 years; 8 female/12 male). Fiber density between the internal part of the globus pallidus and selective target regions, as well as the diffusion measures of fractional anisotropy (FA) and mean diffusivity (MD) were analyzed and compared between different etiologies. Results: Patients with acquired dystonia presented higher fiber density to the premotor cortex and putamen and lower FA values in the thalamus compared to patients with inherited/idiopathic dystonia. MD in the pre- motor cortex was higher in patients with acquired dystonia, while it was lower in the thalamus. Conclusion: Diffusion MRI reveals microstructural and network alterations in patients with dystonia of different etiologies.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Loução, Ricardo UNSPECIFIED https://orcid.org/0000-0002-0310-0352 UNSPECIFIED Burkhardt, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED https://orcid.org/0000-0003-3712-2258 UNSPECIFIED Dembek, Till A. UNSPECIFIED https://orcid.org/0000-0001-7023-146X UNSPECIFIED Heiden, Petra UNSPECIFIED https://orcid.org/0000-0001-7295-5437 UNSPECIFIED Cirak, Sebahattin UNSPECIFIED https://orcid.org/0009-0001-1011-2618 UNSPECIFIED Al-Fatly, Bassam UNSPECIFIED https://orcid.org/0000-0003-0067-6177 UNSPECIFIED Treuer, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED https://orcid.org/0000-0002-5274-7929 UNSPECIFIED Hoevels, Mauritius UNSPECIFIED UNSPECIFIED UNSPECIFIED Koy, Anne UNSPECIFIED https://orcid.org/0000-0002-7991-4432 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-813971
Identification Number:	10.1016/j.neuroimage.2024.120507
Journal or Publication Title:	NeuroImage
Volume:	287
Page Range:	pp. 1-9
Number of Pages:	9
Date:	15 February 2024
Publisher:	Elsevier
ISSN:	1053-8119
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin Faculty of Medicine > Neurochirurgie > Klinik für Allgemeine Neurochirurgie Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Dystonia ; Connectivity ; Children English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81397