Universität zu Köln

Schüller, Thomas ORCID: 0000-0003-1232-7871, Huys, Daniel, Kohl, Sina, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Dembek, Till A. ORCID: 0000-0001-7023-146X, Kuhn, Jens, Baldermann, Juan Carlos and Smith, Ezra E. (2024). Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity. Brain Stimulation, 17 (2). pp. 197-201. Elsevier. ISSN 1935-861X

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Abstract

Background: Deep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown. Objective: We assessed whether DBS modulates beta activity at fronto-central electrodes. We explored concurrent EEG sources and probabilistic stimulation maps. Methods: Resting state EEG of TS patients treated with thalamic DBS was recorded in repeated DBS-on and DBS- off states. A mixed linear model was employed for statistical evaluation. EEG sources were estimated with eLORETA. Thalamic probabilistic stimulation maps were obtained by assigning beta power difference scores (DBS-on minus DBS-off) to stimulation sites. Results: We observed increased beta power in DBS-on compared to DBS-off states. Modulation of cortical beta activity was localized to the midcingulate cortex. Beta modulation was more pronounced when stimulating the thalamus posteriorly, peaking in the ventral posterior nucleus. Conclusion: Thalamic DBS in TS patients modulates beta frequency oscillations presumably important for sensorimotor function and relevant to TS pathophysiology.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Schüller, Thomas UNSPECIFIED https://orcid.org/0000-0003-1232-7871 UNSPECIFIED Huys, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohl, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED https://orcid.org/0000-0002-5274-7929 UNSPECIFIED Dembek, Till A. UNSPECIFIED https://orcid.org/0000-0001-7023-146X UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Ezra E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814042
Identification Number:	10.1016/j.brs.2024.01.011
Journal or Publication Title:	Brain Stimulation
Volume:	17
Number:	2
Page Range:	pp. 197-201
Number of Pages:	5
Date:	April 2024
Publisher:	Elsevier
ISSN:	1935-861X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Psychiatrie und Psychotherapie > Klinik und Poliklinik für Psychiatrie und Psychotherapie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Tourette syndrome ; Deep brain stimulation ; Beta oscillations ; Midcingulate cortex ; Ventral posterior thalamus English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81404