Universität zu Köln

Pütz, Sina M. ORCID: 0000-0002-8886-4596, Wingen-Heimann, Sebastian M. ORCID: 0000-0002-4232-6944, Classen, Annika Y. ORCID: 0000-0003-2905-5139, Blau, Igor-Wolfgang, Bug, Gesine ORCID: 0000-0003-2359-131X, Hebermehl, Corinna, Kraus, Sabrina ORCID: 0000-0001-8954-4220, Penack, Olaf, Rettig, Andrés R., Schmitt, Timo, Steinbrunn, Torsten ORCID: 0000-0002-8793-9998, Teschner, Daniel ORCID: 0000-0001-7351-8060, Vehreschild, Maria J.G.T., Wehr, Claudia and Vehreschild, J. Janne ORCID: 0000-0002-5446-7170 (2024). Real-world experience with letermovir for cytomegalovirus-prophylaxis after allogeneic hematopoietic cell transplantation: A multi-centre observational study. Journal of Infection, 89 (2). pp. 1-8. Elsevier. ISSN 0163-4453

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Abstract

[Artikel-Nr.: 106220] Objectives: Efficacy and safety of letermovir as prophylaxis for clinically significant cytomegalovirus infections (csCVMi) was evaluated in randomised controlled trials while most of the real-world studies are single-centre experiences. Methods: We performed a retrospective, multi-centre case-control study at six German university hospitals to evaluate clinical experiences in patients receiving CMV prophylaxis with letermovir (n = 200) compared to controls without CMV prophylaxis (n = 200) during a 48-week follow-up period after allogeneic hematopoietic cell transplantation (aHCT). Results: The incidence of csCMVi after aHCT was significantly reduced in the letermovir (34%, n = 68) compared to the control group (56%, n = 112; p < 0.001). Letermovir as CMV prophylaxis (OR 0.362) was found to be the only independent variable associated with the prevention of csCMVi. Patients receiving letermovir showed significantly better survival compared to the control group (HR = 1.735, 95% CI: 1.111–2.712; p = 0.014). Of all csCMVi, 46% (n = 31) occurred after discontinuation of letermovir prophylaxis. Severe neutropenia (<500 neutrophils/µL) on the day of the stem cell infusion was the only independent variable for an increased risk of csCMVi after the end of letermovir prophylaxis. Conclusions: Our study highlights the preventive effects of letermovir on csCMVi after aHCT. A substantial proportion of patients developed a csCMVi after discontinuation of letermovir. In particular, patients with severe neutropenia require specific attention after drug discontinuation.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Pütz, Sina M. UNSPECIFIED https://orcid.org/0000-0002-8886-4596 UNSPECIFIED Wingen-Heimann, Sebastian M. UNSPECIFIED https://orcid.org/0000-0002-4232-6944 UNSPECIFIED Classen, Annika Y. UNSPECIFIED https://orcid.org/0000-0003-2905-5139 UNSPECIFIED Blau, Igor-Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Bug, Gesine UNSPECIFIED https://orcid.org/0000-0003-2359-131X UNSPECIFIED Hebermehl, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Kraus, Sabrina UNSPECIFIED https://orcid.org/0000-0001-8954-4220 UNSPECIFIED Penack, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Rettig, Andrés R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinbrunn, Torsten UNSPECIFIED https://orcid.org/0000-0002-8793-9998 UNSPECIFIED Teschner, Daniel UNSPECIFIED https://orcid.org/0000-0001-7351-8060 UNSPECIFIED Vehreschild, Maria J.G.T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wehr, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, J. Janne UNSPECIFIED https://orcid.org/0000-0002-5446-7170 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814248
Identification Number:	10.1016/j.jinf.2024.106220
Journal or Publication Title:	Journal of Infection
Volume:	89
Number:	2
Page Range:	pp. 1-8
Number of Pages:	1
Date:	August 2024
Publisher:	Elsevier
ISSN:	0163-4453
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO)
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Letermovir ; Cytomegalovirus ; Allogeneic hematopoietic cell transplantation ; Real-world data English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81424