Universität zu Köln

Pantić, Nikola, Barać, Aleksandra, Mano, Vasilika, Dedeić-Ljubović, Amela, Malkodanski, Ivan, Jaksić, Ozren, Gkentzi, Despoina ORCID: 0000-0002-1421-0813, Mitrović, Mirjana, Munteanu, Oxana ORCID: 0000-0001-5911-9426, Šišević, Dijana, Stojanoski, Zlate, Popescu, Oana, Todorović, Jelena, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Salmanton-García, Jon ORCID: 0000-0002-6766-8297, Dumitru, Irina-Magdalena, Stathi, Angeliki, Mandros, Charalampos, Travar, Maja, Milobratović, Danica, Mantzana, Paraskevi, Zaharia, Mihaela, Ostojić, Alen, Chatzimsochou, Athanasios, Tonkić, Marija, Otašević, Suzana, Jovanović, Danijela, Vukosavljević, Nikola, Bukovski, Suzana, Philipova, Ivva, Laura, Vlad Jeni, Savić, Aleksandar, Lupse, Mihaela, Manuela, Arbune, Dimova, Diana, Cviljević, Sabina, Orfanidou, Maria, Paramythiotou, Elisabeth, Cheran, Cristina Alexandra, Gartzonika, Konstantina, Skvarc, Miha, Nikolcheva-Todorova, Lidiya, Velikova, Tsvetelina, Panopoulou, Maria, Tihic, Nijaz, Bibić, Tamara, Tomic, Viktorija, Daniela, Serban Elena, Donchev, Krasimir, Sular, Floredana, Moroti, Ruxandra, Voichiţa, Lăzureanu Elena, Valković, Toni and Maraki, Sofija (2024). Mapping the path to excellence: Evaluation of the diagnostic and treatment tools for invasive fungal infections in the balkans. Journal of Infection and Public Health, 17 (8). pp. 1-8. Elsevier. ISSN 1876-0341

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Abstract

[Artikel-Nr.: 102493] Background: In the Balkans, rising concerns about invasive fungal infections over the past decade stem from various factors. Primarily, there has been a notable uptick in immunocompromised individuals, including those with chronic illnesses like immunological and hematological diseases. Thus, it is essential to assess the region’s laboratory capabilities and the availability of antifungals. This evaluation is vital for gauging the preparedness to diagnose and treat fungal infections effectively, thus minimizing their public health impact. Methods: Data were collected via an online questionnaire targeting healthcare professionals specializing in relevant fields across diverse healthcare settings in Balkan countries. The survey covered various aspects, including diagnostic methods, imaging techniques, and available antifungal armamentarium. Results: Responses were obtained from 50 institutions across the Balkans. While conventional diagnostic methods like microscopy (96 %) and culture (100 %) diagnostics were widely available, access to newer diagnostic tools such as molecular assays (61 %) were limited, often relying on outsourced services. Imaging modalities like ultrasound (100 %) and CT scans (93 %) were universally accessible. A variety of antifungal drugs were available, including amphotericin B formulations (80 %), echinocandins (79 %), and triazoles (100 %). However, access to newer agents like posaconazole (62 %) and isavuconazole (45 %) was incon- sistent. Therapeutic drug monitoring (53 %) services were also limited. Conclusion: The study underscores the need for equitable access to diagnostic facilities and antifungal treatments across healthcare settings in the Balkan geographic region. Improving access to molecular di- agnostic tools and essential antifungal drugs, as well as implementing therapeutic drug monitoring, would optimize the management of fungal infections in the region.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Pantić, Nikola UNSPECIFIED UNSPECIFIED UNSPECIFIED Barać, Aleksandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Mano, Vasilika UNSPECIFIED UNSPECIFIED UNSPECIFIED Dedeić-Ljubović, Amela UNSPECIFIED UNSPECIFIED UNSPECIFIED Malkodanski, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaksić, Ozren UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkentzi, Despoina UNSPECIFIED https://orcid.org/0000-0002-1421-0813 UNSPECIFIED Mitrović, Mirjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Munteanu, Oxana UNSPECIFIED https://orcid.org/0000-0001-5911-9426 UNSPECIFIED Šišević, Dijana UNSPECIFIED UNSPECIFIED UNSPECIFIED Stojanoski, Zlate UNSPECIFIED UNSPECIFIED UNSPECIFIED Popescu, Oana UNSPECIFIED UNSPECIFIED UNSPECIFIED Todorović, Jelena UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Salmanton-García, Jon UNSPECIFIED https://orcid.org/0000-0002-6766-8297 UNSPECIFIED Dumitru, Irina-Magdalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Stathi, Angeliki UNSPECIFIED UNSPECIFIED UNSPECIFIED Mandros, Charalampos UNSPECIFIED UNSPECIFIED UNSPECIFIED Travar, Maja UNSPECIFIED UNSPECIFIED UNSPECIFIED Milobratović, Danica UNSPECIFIED UNSPECIFIED UNSPECIFIED Mantzana, Paraskevi UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaharia, Mihaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostojić, Alen UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatzimsochou, Athanasios UNSPECIFIED UNSPECIFIED UNSPECIFIED Tonkić, Marija UNSPECIFIED UNSPECIFIED UNSPECIFIED Otašević, Suzana UNSPECIFIED UNSPECIFIED UNSPECIFIED Jovanović, Danijela UNSPECIFIED UNSPECIFIED UNSPECIFIED Vukosavljević, Nikola UNSPECIFIED UNSPECIFIED UNSPECIFIED Bukovski, Suzana UNSPECIFIED UNSPECIFIED UNSPECIFIED Philipova, Ivva UNSPECIFIED UNSPECIFIED UNSPECIFIED Laura, Vlad Jeni UNSPECIFIED UNSPECIFIED UNSPECIFIED Savić, Aleksandar UNSPECIFIED UNSPECIFIED UNSPECIFIED Lupse, Mihaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Manuela, Arbune UNSPECIFIED UNSPECIFIED UNSPECIFIED Dimova, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Cviljević, Sabina UNSPECIFIED UNSPECIFIED UNSPECIFIED Orfanidou, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Paramythiotou, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheran, Cristina Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Gartzonika, Konstantina UNSPECIFIED UNSPECIFIED UNSPECIFIED Skvarc, Miha UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikolcheva-Todorova, Lidiya UNSPECIFIED UNSPECIFIED UNSPECIFIED Velikova, Tsvetelina UNSPECIFIED UNSPECIFIED UNSPECIFIED Panopoulou, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Tihic, Nijaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Bibić, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomic, Viktorija UNSPECIFIED UNSPECIFIED UNSPECIFIED Daniela, Serban Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Donchev, Krasimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Sular, Floredana UNSPECIFIED UNSPECIFIED UNSPECIFIED Moroti, Ruxandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Voichiţa, Lăzureanu Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Valković, Toni UNSPECIFIED UNSPECIFIED UNSPECIFIED Maraki, Sofija UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814275
Identification Number:	10.1016/j.jiph.2024.102493
Journal or Publication Title:	Journal of Infection and Public Health
Volume:	17
Number:	8
Page Range:	pp. 1-8
Number of Pages:	8
Date:	August 2024
Publisher:	Elsevier
ISSN:	1876-0341
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO) Faculty of Medicine > Weitere > Zentrum für Klinische Studien
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Fungal infections ; Balkans ; Laboratory capacity ; Antifungal treatment ; Diagnostic methods English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81427