Universität zu Köln

Rostami, Vahid ORCID: 0000-0002-3851-0220, Rost, Thomas, Schmitt, Felix Johannes ORCID: 0000-0002-5902-9372, van Albada, Sacha Jennifer ORCID: 0000-0003-0682-4855, Riehle, Alexa ORCID: 0000-0001-5890-3999 and Nawrot, Martin Paul ORCID: 0000-0003-4133-6419 (2024). Spiking attractor model of motor cortex explains modulation of neural and behavioral variability by prior target information. Nature Communications, 15 (1). pp. 1-17. Springer Nature. ISSN 2041-1723

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Abstract

[Artikel-Nr.: 6304] When preparing a movement, we often rely on partial or incomplete information, which can decrement task performance. In behaving monkeys we show that the degree of cued target information is reflected in both, neural variability in motor cortex and behavioral reaction times. We study the underlying mechanisms in a spiking motor-cortical attractor model. By introducing a biologically realistic network topology where excitatory neuron clusters are locally balanced with inhibitory neuron clusters we robustly achieve metastable network activity across a wide range of network parameters. In application to the monkey task, the model performs target-specific action selection and accurately reproduces the task-epoch dependent reduction of trial-to-trial variability in vivo where the degree of reduction directly reflects the amount of processed target information, while spiking irregularity remained constant throughout the task. In the context of incomplete cue information, the increased target selection time of the model can explain increased behavioral reaction times. We conclude that context-dependent neural and behavioral variability is a signum of attractor computation in the motor cortex.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Rostami, Vahid UNSPECIFIED https://orcid.org/0000-0002-3851-0220 UNSPECIFIED Rost, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Felix Johannes UNSPECIFIED https://orcid.org/0000-0002-5902-9372 UNSPECIFIED van Albada, Sacha Jennifer UNSPECIFIED https://orcid.org/0000-0003-0682-4855 UNSPECIFIED Riehle, Alexa UNSPECIFIED https://orcid.org/0000-0001-5890-3999 UNSPECIFIED Nawrot, Martin Paul UNSPECIFIED https://orcid.org/0000-0003-4133-6419 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814784
Identification Number:	10.1038/s41467-024-49889-4
Journal or Publication Title:	Nature Communications
Volume:	15
Number:	1
Page Range:	pp. 1-17
Number of Pages:	17
Date:	26 July 2024
Publisher:	Springer Nature
ISSN:	2041-1723
Language:	English
Faculty:	External institution Faculty of Mathematics and Natural Sciences
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Mathematics and Natural Sciences > Department of Biology > Zoologisches Institut
Subjects:	Life sciences
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81478