Universität zu Köln

Kirangwa, Joseph ORCID: 0000-0002-9393-0500, Laetsch, Dominik R., King, Erna, Stevens, Lewis, Blaxter, Mark, Holovachov, Oleksandr and Schiffer, Philipp ORCID: 0000-0001-6776-0934 (2024). Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement. Scientific Reports, 14 (1). pp. 1-13. Springer Nature. ISSN 2045-2322

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Abstract

[Artikel-Nr.: 29513] Hox genes are central to metazoan body plan formation, patterning and evolution, playing a critical role in cell fate decisions early in embryonic development in invertebrates and vertebrates. While the archetypical Hox gene cluster consists of members of nine ortholog groups (HOX1-HOX9), arrayed in close linkage in the order in which they have their anterior-posterior patterning effects, nematode Hox gene sets do not fit this model. The Caenorhabditis elegans Hox gene set is not clustered and contains only six Hox genes from four of the ancestral groups. The pattern observed in C. elegans is not typical of the phylum, and variation in orthologue set presence and absence and in genomic organisation has been reported. Recent advances in genome sequencing have resulted in the availability of many novel genome assemblies in Nematoda, especially from taxonomic groups that had not been analysed previously. Here, we explored Hox gene complements in high-quality genomes of 80 species from all major clades of Nematoda to understand the evolution of this key set of body pattern genes and especially to probe the origins of the “dispersed” cluster observed in C. elegans. We also included the recently available high-quality genomes of some Nematomorpha as an outgroup. We find that nematodes can have Hox genes from up to six orthology groups. While nematode Hox “clusters” are often interrupted by unrelated genes we identify species in which the cluster is intact and not dispersed.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kirangwa, Joseph UNSPECIFIED https://orcid.org/0000-0002-9393-0500 UNSPECIFIED Laetsch, Dominik R. UNSPECIFIED UNSPECIFIED UNSPECIFIED King, Erna UNSPECIFIED UNSPECIFIED UNSPECIFIED Stevens, Lewis UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaxter, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Holovachov, Oleksandr UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffer, Philipp UNSPECIFIED https://orcid.org/0000-0001-6776-0934 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814852
Identification Number:	10.1038/s41598-024-79962-3
Journal or Publication Title:	Scientific Reports
Volume:	14
Number:	1
Page Range:	pp. 1-13
Number of Pages:	13
Date:	27 November 2024
Publisher:	Springer Nature
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Zoologisches Institut
Subjects:	Life sciences
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81485