Universität zu Köln

Hoefer, Karolin Charlotte ORCID: 0000-0001-8284-9849, Barbe, Anna Greta ORCID: 0000-0003-0169-2582, Adams, Anne ORCID: 0000-0003-3286-1131, Schoppmeier, Christoph ORCID: 0000-0002-3269-8920, Wicht, Michael Jochen ORCID: 0000-0003-4693-7184, Weber, Lutz T. ORCID: 0000-0003-4116-598X, Noack, Michael J. ORCID: 0000-0001-5303-4616 and Graf, Isabelle ORCID: 0000-0002-9598-8861 (2024). Halitosis in young patients with chronic kidney disease: findings from a randomized controlled trial. Head & Face Medicine, 20 (1). pp. 1-10. Springer Nature. ISSN 1746-160X

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Abstract

[Artikel-Nr.: 20] Background: Chronic kidney disease (CKD) directly affects oral health. Yet data about halitosis in young CKD patients and the impact of dental prophylaxis is limited. Therefore, as part of this randomized clinical trial, halitosis in young CKD patients undergoing intensive or standard oral preventive procedures was to be explored. Methods: Three volatile sulfur compounds (hydrogen sulfide, methyl mercaptan and dimethyl sulfide) were measured in 30 young patients with CKD (mean age 14.2 years; 16 males, 14 females). Breath samples were taken after 3 and 6 months and analyzed with selective gas chromatography (OralChroma). Tongue coating (Winkel Index) and clinical indices to determine local inflammation or oral hygiene (Papillary Bleeding Index and Quigley-Hein Index) were assessed. Within an extended anamnesis, patients and their mothers and nurses were questioned about the perceived halitosis. Corresponding quotes were noted verbatim. Patients were randomized to either intensive need-related oral health care measures (oral preventative program, OPP) or a one-stage standard prevention (treatment as usual, TAU). Results: While there were no differences in volatile sulfur compound levels between TAU and OPP at the three time points of measurements (p > 0.05), there was a tendency towards a reduction in dimethyl sulfide and hydrogen sulfide of affected patients within the OPP group over time. Looking at potential differences between both groups with regard to tongue coating, significant differences were observed between baseline and 3 months after study start in the OPP group, and between baseline and 6 months after study start in the TAU group (p < 0.05). The burden of halitosis was frequently reported by patients’ mothers and nurses. Conclusions: Young CKD patients regularly suffered from halitosis and dimethyl sulfide was its main source. Preventive measures mainly resulted in a reduction of tongue coating. Trial registration: The German Clinical Trial Register (# DRKS00010580).

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Hoefer, Karolin Charlotte UNSPECIFIED https://orcid.org/0000-0001-8284-9849 UNSPECIFIED Barbe, Anna Greta UNSPECIFIED https://orcid.org/0000-0003-0169-2582 UNSPECIFIED Adams, Anne UNSPECIFIED https://orcid.org/0000-0003-3286-1131 UNSPECIFIED Schoppmeier, Christoph UNSPECIFIED https://orcid.org/0000-0002-3269-8920 UNSPECIFIED Wicht, Michael Jochen UNSPECIFIED https://orcid.org/0000-0003-4693-7184 UNSPECIFIED Weber, Lutz T. UNSPECIFIED https://orcid.org/0000-0003-4116-598X UNSPECIFIED Noack, Michael J. UNSPECIFIED https://orcid.org/0000-0001-5303-4616 UNSPECIFIED Graf, Isabelle UNSPECIFIED https://orcid.org/0000-0002-9598-8861 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815548
Identification Number:	10.1186/s13005-024-00428-y
Journal or Publication Title:	Head & Face Medicine
Volume:	20
Number:	1
Page Range:	pp. 1-10
Number of Pages:	10
Date:	15 May 2024
Publisher:	Springer Nature
ISSN:	1746-160X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin Faculty of Medicine > Medizinische Statistik und Bioinformatik > Institut für Medizinische Statistik und Bioinformatik � IMSB Faculty of Medicine > Zahn-, Mund- und Kieferheilkunde > Poliklinik für Kieferorthopädie Faculty of Medicine > Zahn-, Mund- und Kieferheilkunde > Poliklinik für Zahnerhaltung und Parodontologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Chronic kidney disease ; Halitosis ; Children ; Adolescents English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81554