Universität zu Köln

Ophey, Anja ORCID: 0000-0001-5858-7762, Röttgen, Sinah ORCID: 0000-0002-7553-2111, Pauquet, Julia ORCID: 0000-0002-4254-9945, Weiß, Kim-Lara ORCID: 0000-0002-5918-070X, Scharfenberg, Daniel ORCID: 0000-0003-2781-3143, Doppler, Christopher E. J. ORCID: 0000-0002-1341-0389, Seger, Aline ORCID: 0000-0003-3135-8091, Hansen, Clint ORCID: 0000-0003-4813-3868, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Sommerauer, Michael ORCID: 0000-0001-5723-9766 and Kalbe, Elke ORCID: 0000-0001-8603-2545 (2024). Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD. Trials, 25 (1). pp. 1-15. Springer Nature. ISSN 1745-6215

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Abstract

[Artikel-Nr.: 428] Background: Isolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive dysfunctions predict earlier phenotypic conversion from iRBD to Parkinson’s disease and Lewy body dementia, cognitive training focusing on executive functions could have disease-modifying effects for individuals with iRBD. Methods: The study CogTrAiL-RBD investigates the short- and long-term effectiveness and the feasibility and underlying neural mechanisms of a cognitive training intervention for individuals with iRBD. The intervention consists of a 5-week digital cognitive training accompanied by a module promoting a healthy, active lifestyle. In this monocentric, single-blinded, delayed-start randomized controlled trial, the intervention’s effectiveness will be evaluated compared to an initially passive control group that receives the intervention in the second, open-label phase of the study. Eighty individuals with iRBD confirmed by polysomnography will be consecutively recruited from the continuously expanding iRBD cohort at the University Hospital Cologne. The evaluation will focus on cognition and additional neuropsychological and motor variables. Furthermore, the study will examine the feasibility of the intervention, effects on physical activity assessed by accelerometry, and interrogate the intervention’s neural effects using magnetic resonance imaging and polysomnography. Besides, a healthy, age-matched control group (HC) will be examined at the first assessment time point, enabling a cross-sectional comparison between individuals with iRBD and HC. Discussion: This study will provide insights into whether cognitive training and psychoeducation on a healthy, active lifestyle have short- and long-term (neuro-)protective effects for individuals with iRBD. Trial registration: The study was prospectively registered in the German Clinical Trial Register (DRKS00024898) on 2022–03-11, https://drks.de/search/de/trial/DRKS00024898 . Protocol version: V5 2023–04-24.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Ophey, Anja UNSPECIFIED https://orcid.org/0000-0001-5858-7762 UNSPECIFIED Röttgen, Sinah UNSPECIFIED https://orcid.org/0000-0002-7553-2111 UNSPECIFIED Pauquet, Julia UNSPECIFIED https://orcid.org/0000-0002-4254-9945 UNSPECIFIED Weiß, Kim-Lara UNSPECIFIED https://orcid.org/0000-0002-5918-070X UNSPECIFIED Scharfenberg, Daniel UNSPECIFIED https://orcid.org/0000-0003-2781-3143 UNSPECIFIED Doppler, Christopher E. J. UNSPECIFIED https://orcid.org/0000-0002-1341-0389 UNSPECIFIED Seger, Aline UNSPECIFIED https://orcid.org/0000-0003-3135-8091 UNSPECIFIED Hansen, Clint UNSPECIFIED https://orcid.org/0000-0003-4813-3868 UNSPECIFIED Fink, Gereon R. UNSPECIFIED https://orcid.org/0000-0002-8230-1856 UNSPECIFIED Sommerauer, Michael UNSPECIFIED https://orcid.org/0000-0001-5723-9766 UNSPECIFIED Kalbe, Elke UNSPECIFIED https://orcid.org/0000-0001-8603-2545 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815726
Identification Number:	10.1186/s13063-024-08265-9
Journal or Publication Title:	Trials
Volume:	25
Number:	1
Page Range:	pp. 1-15
Number of Pages:	15
Date:	28 June 2024
Publisher:	Springer Nature
ISSN:	1745-6215
Language:	English
Faculty:	External institution Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Medizinische Psychologie > Abteilung für Medizinische Psychologie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie
Subjects:	Psychology Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Isolated REM sleep behavior disorder ; Cognitive training ; Randomized controlled trial English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81572