Universität zu Köln

Goertz, Lukas ORCID: 0000-0002-2620-7611, Liebig, Thomas, Siebert, Eberhard, Zopfs, David ORCID: 0000-0001-9978-7453, Pennig, Lenhard ORCID: 0000-0002-6606-9313, Pflaeging, Muriel, Schlamann, Marc ORCID: 0000-0002-7734-611X, Radomi, Alexandra, Dorn, Franziska and Kabbasch, Christoph ORCID: 0000-0003-3712-2258 (2024). Lessons learned from 12 years using the Woven Endobridge for the treatment of cerebral aneurysms in a multi-center series. Scientific Reports, 14 (1). pp. 1-11. Springer Nature. ISSN 2045-2322

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Abstract

[Artikel-Nr.: 24212] Intrasaccular flow disruption with the Woven Endobridge (WEB) has become a well-established endovascular technique for the treatment of intracranial aneurysms. This study presents our 12-year experience with the WEB and evaluates its evolving indications, procedures, and outcomes. A consecutive series of 324 aneurysms treated with WEB between 2011 and 2023 at three neurovascular centers was retrospectively analyzed and the study group was divided into four treatment periods. Uni- and multivariate analyses were performed to evaluate factors associated with technical success, thromboembolic complications, and angiographic outcome. The mean aneurysm size was 7.0 ± 3.6 mm and decreased during the study period, while the proportion of atypical sites for WEB implantation increased. WEB implantation was technically successful in 96.0%, and the ratio of WEB width to dome width increased during the study period, indicating oversizing. The neurological complication rate was 4.9% (1.5% major, 3.4% minor) and the mid-term complete occlusion rate was 60.6% (81.9% adequate occlusion), with no statistical differences in either outcome measure between the study periods. In multivariate analyses, the use of WEB 17 was associated with increased technical success (HR: 7.4, 95%CI: 2.4-23.6, p <0.01), whereas ruptured aneurysm status (HR: 2.5, 95%CI: 1.0-6.0, p =0.04) and the use of additional stents (HR: 4.8, 95%CI: 1.6-14.4, p <0.01) predicted thromboembolic complications. Appropriate oversizing of the WEB favored mid-term complete occlusion (HR: 10.5, 95%CI: 1.3-83.3, p =0.03). The results suggest an expansion of the indications for WEB implantation and highlight the importance of oversizing for treatment efficacy.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Goertz, Lukas UNSPECIFIED https://orcid.org/0000-0002-2620-7611 UNSPECIFIED Liebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebert, Eberhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Zopfs, David UNSPECIFIED https://orcid.org/0000-0001-9978-7453 UNSPECIFIED Pennig, Lenhard UNSPECIFIED https://orcid.org/0000-0002-6606-9313 UNSPECIFIED Pflaeging, Muriel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED https://orcid.org/0000-0002-7734-611X UNSPECIFIED Radomi, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorn, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED https://orcid.org/0000-0003-3712-2258 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815882
Identification Number:	10.1038/s41598-024-75064-2
Journal or Publication Title:	Scientific Reports
Volume:	14
Number:	1
Page Range:	pp. 1-11
Date:	16 October 2024
Publisher:	Springer Nature
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Radiologische Diagnostik > Institut und Poliklinik für Radiologische Diagnostik
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Aneurysm occlusion ; Angiographic ; Flow-disruption ; Intrasaccular ; Stroke English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81588