Universität zu Köln

Schmitz, Jan ORCID: 0000-0003-0282-097X, Aeschbach, Daniel, Beccard, Inga, Frings, Nina, Hinkelbein, Jochen ORCID: 0000-0003-3585-9459, Jordan, Jens, Kammerer, Tobias ORCID: 0000-0001-8920-7187, Liebold, Felix, Limper, Ulrich ORCID: 0000-0001-9927-4180, Post, Titiaan, Schick, Volker ORCID: 0000-0002-2090-7836, Tank, Jens and Elmenhorst, Eva-Maria (2024). Chest compression quality decreases in hypoxic conditions simulating an airliner cabin at cruising altitude: a randomized, controlled, double-blind Manikin Study. Scientific Reports, 14 (1). pp. 1-9. Springer Nature. ISSN 2045-2322

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Abstract

[Artikel-Nr.: 25971] Air traveler numbers are predicted to reach 4.0 billion in 2024. Between 1/15,000–50,000 passengers will experience acute medical problems inflight with cardiac arrests requiring cardiopulmonary resuscitation (CPR) accounting for 0.3% of medical emergencies. Hypoxia in airplane cabins could impair oxygenation and physical performance of caregivers. We conducted a randomized controlled, double-blind study to test the hypothesis that hypoxia decreases the effectiveness in performing CPR. We randomized 24 healthcare professionals to two different study arms, each consisting of two conditions: arm (1) ‘hypoxia (FiO 2 15%, equivalent to 2400 m altitude)’ versus ‘normoxia’; arm (2) ‘hypoxia + supplemental oxygen’ versus ‘normoxia + supplemental oxygen’. The order of conditions was counterbalanced and a minimum wash-out period of 24 h was granted between conditions. In each condition participants performed a 5-min cardiac compression only CPR (CCO-CPR) using a full-body manikin after one, three and six hours in an altitude chamber. Mixed ANOVAs with post-hoc false-discovery-rate adjusted pairwise comparisons indicated that although compression frequency was maintained, the number of compressions with correct depth was decreased at all times during hypoxia compared to normoxia (all p < 0.002). After 6 h hypoxia exposure, mean compression depth was below the recommended compression depth defined by ERC/AHA guidelines and reduced compared to normoxia (42.4 ± 12.6 mm vs. 54.6 ± 4.3 mm, p < 0.0001). Supplemental oxygen during CCO-CPR in hypoxia prevented the decrease of compression-depth (55.3 ± 3 mm). Extended hypoxia exposure akin to conditions in airplane cabins can reduce quality of chest compressions during CPR. Supplemental oxygen for healthcare providers is an effective countermeasure.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Schmitz, Jan UNSPECIFIED https://orcid.org/0000-0003-0282-097X UNSPECIFIED Aeschbach, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Beccard, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Frings, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinkelbein, Jochen UNSPECIFIED https://orcid.org/0000-0003-3585-9459 UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kammerer, Tobias UNSPECIFIED https://orcid.org/0000-0001-8920-7187 UNSPECIFIED Liebold, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Limper, Ulrich UNSPECIFIED https://orcid.org/0000-0001-9927-4180 UNSPECIFIED Post, Titiaan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Volker UNSPECIFIED https://orcid.org/0000-0002-2090-7836 UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, Eva-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815941
Identification Number:	10.1038/s41598-024-77149-4
Journal or Publication Title:	Scientific Reports
Volume:	14
Number:	1
Page Range:	pp. 1-9
Date:	29 October 2024
Publisher:	Springer Nature
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Anästhesiologie und Operative Intensivmedizin > Klinik für Anästhesiologie und Operative Intensivmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language CPR ; Hypoxia, Manikin, In-flight medical emergency, Resuscitation English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81594