Universität zu Köln

Arolt, Christoph ORCID: 0000-0002-6366-2285, Scheel, Andreas H. ORCID: 0000-0003-0244-1646, Dugan, Margaret, Wild, Robert ORCID: 0000-0001-9182-3587, Richartz, Vanessa, Holz, Barbara, Brägelmann, Johannes ORCID: 0000-0002-1306-2169, Wagener-Ryczek, Svenja ORCID: 0000-0002-2870-5606, Merkelbach-Bruse, Sabine ORCID: 0000-0002-0312-5760, Wolf, Juergen ORCID: 0000-0001-8833-8812, Buettner, Reinhard ORCID: 0000-0001-8806-4786, Catanzariti, Luigi, Scheffler, Matthias ORCID: 0000-0002-9031-1368 and Hillmer, Axel M. ORCID: 0000-0002-3381-7266 (2024). Benchmark of screening markers for KEAP1/NFE2L2 mutations and joint analysis with the K1N2-score. npj Precision Oncology, 8 (1). pp. 1-6. Springer Nature. ISSN 2397-768X

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Abstract

[Artikel-Nr.: 259] Our recently published K1N2-score robustly predicts KEAP1/NFE2L2 -mutations and pathway activation status, while its accessibility might be limited. We tested if the RNA expression data of six pathway-related genes and NQO1-IHC might be a reliable alternative using 348 KEAP1/NFE2L2 mutation-enriched NSCLC. While TXNRD1 RNA testing was the best-performing single-gene test, the combination of single-gene screening and validation with the K1N2-score achieved the highest performance when predicting mutation status or pathway activation.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Arolt, Christoph UNSPECIFIED https://orcid.org/0000-0002-6366-2285 UNSPECIFIED Scheel, Andreas H. UNSPECIFIED https://orcid.org/0000-0003-0244-1646 UNSPECIFIED Dugan, Margaret UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, Robert UNSPECIFIED https://orcid.org/0000-0001-9182-3587 UNSPECIFIED Richartz, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Holz, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Brägelmann, Johannes UNSPECIFIED https://orcid.org/0000-0002-1306-2169 UNSPECIFIED Wagener-Ryczek, Svenja UNSPECIFIED https://orcid.org/0000-0002-2870-5606 UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED https://orcid.org/0000-0002-0312-5760 UNSPECIFIED Wolf, Juergen UNSPECIFIED https://orcid.org/0000-0001-8833-8812 UNSPECIFIED Buettner, Reinhard UNSPECIFIED https://orcid.org/0000-0001-8806-4786 UNSPECIFIED Catanzariti, Luigi UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheffler, Matthias UNSPECIFIED https://orcid.org/0000-0002-9031-1368 UNSPECIFIED Hillmer, Axel M. UNSPECIFIED https://orcid.org/0000-0002-3381-7266 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815971
Identification Number:	10.1038/s41698-024-00744-1
Journal or Publication Title:	npj Precision Oncology
Volume:	8
Number:	1
Page Range:	pp. 1-6
Date:	11 November 2024
Publisher:	Springer Nature
ISSN:	2397-768X
Language:	English
Faculty:	Central Institutions / Interdisciplinary Research Centers Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO) Faculty of Medicine > Weitere > Translationale Genomik Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81597