Avelino-Silva, Vivian I., Mayaud, Philippe, Tami, Adriana ORCID: 0000-0002-1918-9144, Miranda, Maria C., Rosenberger, Kerstin D., Alexander, Neal, Nacul, Luis, Segurado, Aluisio, Pohl, Moritz, Bethencourt, Sarah, Villar, Luis A., Viana, Isabelle F. T., Rabello, Renata, Soria, Carmen, Salgado, Silvia P., Gotuzzo, Eduardo, Guzman, Maria G., Martinez, Pedro A., Lopez-Gatell, Hugo, Hegewisch-Taylor, Jennifer, Borja-Aburto, Victor H., Gonzalez, Cesar, Netto, Eduardo M., Villarroel, Paola M. Saba, Hoen, Bruno, Brasil, Patricia, Marques, Ernesto T. A., Rockx, Barry, Koopmans, Marion, de Lamballerie, Xavier, Jaenisch, Thomas, Jaenisch, Thomas, Rosenberger, Kerstin Daniela, Morales, Ivonne, Tobian, Frank, Uhlmann, Lorenz, Pohl, Moritz, Schretzmann, Julius, Leege, Annika, Marques, Ernesto T. A., Marques, Ernesto T. A., Viana, Isabelle F. T., Lins, Roberto D., Bispo de Filippis, Ana Maria, Machado Duarte, Ana Claudia, Espindola, Otavio de Melo, Bonaldo, Myrna, Rabello, Renata, Damasceno, Luana, Mendes-Correa, Maria Cassia, Mayaud, Philippe, Nacul, Luis, Alexander, Neal, Netto, Eduardo Martins, Tami, Adriana ORCID: 0000-0002-1918-9144, Bethencourt, Sarah, Tinedo, Maria Jose, La Rosa, Yenifer, Murillo, Marianela, Angel Villar, Luis, Consuelo Miranda, Maria, Lozano, Anyela, Mauricio Herrera, Victor, Gomez, Adriana, Margarita Gelvez, Rosa, Ortiz, Ricardo, Mauricio Herrera, Victor, Soria, Carmen, Dimitrakis, Lady, Paola Salgado, Silvia, Regato Arrata, Mary, Gotuzzo, Eduardo, Guerra Allison, Humberto, Talledo, Michael, Saba Villarroel, Paola Mariela, Torres, Eric Martinez, Guzman, Maria G., Martinez Rodriguez, Pedro A., Alvarez Vera, Mayling, Galindo Santana, Belkis, Reyes, Alicia, Serrano Alvarez, Silvia, Ferriol Dorticos, Diana, Hegewisch-Taylor, Jennifer, Alpuche-Aranda, Celia, Lopez-Gatell, Hugo, Gonzalez-Diaz, Esteban, Pavia-Ruz, Norma, Hugo Borja-Aburto, Victor, Gonzalez, Cesar, Grajales, Concepcion, Rojas, Teresita, Arriaga, Lumumba, Vallejos, Alfonso, Tynevez, Dominique, Thirion, Laurence, Drexler, Jan Felix, Rockx, Barry, van Gorp, Eric and Koopmans, Marion (2019). Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium. BMC Infect. Dis., 19 (1). LONDON: BMC. ISSN 1471-2334

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Abstract

Background: The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over a wide geographic range within Latin America and the Caribbean, taking into account the dynamic course of the ZIKV epidemic. Methods: Recruitment to the PW cohort will take place in antenatal care clinics. PW will be enrolled regardless of symptoms and followed over the course of pregnancy, approximately every 4 weeks. PW will be revisited at delivery (or after miscarriage/abortion) to assess birth outcomes, including microcephaly and other congenital abnormalities according to the evolving definition of congenital Zika syndrome (CZS). After birth, children will be followed for 2 years in the CH cohort. Follow-up visits are scheduled at ages 1-3, 4-6, 12, and 24 months to assess neurocognitive and developmental milestones. In addition, a NH cohort for the characterization of symptomatic rash/fever illness was designed, including follow-up to capture persisting health problems. Blood, urine, and other biological materials will be collected, and tested for ZIKV and other relevant arboviral diseases (dengue, chikungunya, yellow fever) using RT-PCR or serological methods. A virtual, decentralized biobank will be created. Reciprocal clinical monitoring has been established between partner sites. Substudies of ZIKV seroprevalence, transmission clustering, disabilities and health economics, viral kinetics, the potential role of antibody enhancement, and co-infections will be linked to the cohort studies. Discussion: Results of these large cohort studies will provide better risk estimates for birth defects and other developmental abnormalities associated with ZIKV infection including possible co-factors for the variability of risk estimates between other countries and regions. Additional outcomes include incidence and transmission estimates of ZIKV during and after pregnancy, characterization of short and long-term clinical course following infection and viral kinetics of ZIKV.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Avelino-Silva, Vivian I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayaud, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tami, AdrianaUNSPECIFIEDorcid.org/0000-0002-1918-9144UNSPECIFIED
Miranda, Maria C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenberger, Kerstin D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alexander, NealUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nacul, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Segurado, AluisioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bethencourt, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villar, Luis A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viana, Isabelle F. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabello, RenataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soria, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salgado, Silvia P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gotuzzo, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guzman, Maria G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez, Pedro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Gatell, HugoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hegewisch-Taylor, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borja-Aburto, Victor H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez, CesarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Netto, Eduardo M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villarroel, Paola M. SabaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoen, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brasil, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marques, Ernesto T. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockx, BarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koopmans, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Lamballerie, XavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaenisch, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaenisch, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenberger, Kerstin DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morales, IvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tobian, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uhlmann, LorenzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schretzmann, JuliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leege, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marques, Ernesto T. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marques, Ernesto T. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viana, Isabelle F. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lins, Roberto D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bispo de Filippis, Ana MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado Duarte, Ana ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espindola, Otavio de MeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonaldo, MyrnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabello, RenataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damasceno, LuanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendes-Correa, Maria CassiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayaud, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nacul, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alexander, NealUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Netto, Eduardo MartinsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tami, AdrianaUNSPECIFIEDorcid.org/0000-0002-1918-9144UNSPECIFIED
Bethencourt, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tinedo, Maria JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
La Rosa, YeniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murillo, MarianelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angel Villar, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Consuelo Miranda, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lozano, AnyelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauricio Herrera, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margarita Gelvez, RosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortiz, RicardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauricio Herrera, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soria, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dimitrakis, LadyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paola Salgado, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regato Arrata, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gotuzzo, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guerra Allison, HumbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Talledo, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saba Villarroel, Paola MarielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torres, Eric MartinezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guzman, Maria G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez Rodriguez, Pedro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez Vera, MaylingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galindo Santana, BelkisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reyes, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serrano Alvarez, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferriol Dorticos, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hegewisch-Taylor, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpuche-Aranda, CeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Gatell, HugoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Diaz, EstebanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavia-Ruz, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hugo Borja-Aburto, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez, CesarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grajales, ConcepcionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rojas, TeresitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arriaga, LumumbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vallejos, AlfonsoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tynevez, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thirion, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drexler, Jan FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockx, BarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Gorp, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koopmans, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-123931
DOI: 10.1186/s12879-019-4685-9
Journal or Publication Title: BMC Infect. Dis.
Volume: 19
Number: 1
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2334
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EXTERNAL QUALITY ASSESSMENT; GUILLAIN-BARRE-SYNDROME; BIRTH-DEFECTS; SEXUAL TRANSMISSION; MOLECULAR-DETECTION; BRAZIL; EPIDEMIC; LABORATORIES; TERRITORIES; OUTCOMESMultiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12393

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