Galldiks, Norbert ORCID: 0000-0002-2485-1796, Lohmann, Philipp
ORCID: 0000-0002-5360-046X, Werner, Jan-Michael
ORCID: 0000-0001-7147-4594, Ceccon, Garry, Fink, Gereon R.
ORCID: 0000-0002-8230-1856 and Langen, Karl-Josef
ORCID: 0000-0003-1101-5075
(2020).
Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors.
Expert Rev. Anticancer Ther, 20 (1).
S. 9 - 16.
ABINGDON:
TAYLOR & FRANCIS LTD.
ISSN 1744-8328
Abstract
Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer. Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized. Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-124081 | ||||||||||||||||||||||||||||
DOI: | 10.1080/14737140.2020.1705788 | ||||||||||||||||||||||||||||
Journal or Publication Title: | Expert Rev. Anticancer Ther | ||||||||||||||||||||||||||||
Volume: | 20 | ||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||
Page Range: | S. 9 - 16 | ||||||||||||||||||||||||||||
Date: | 2020 | ||||||||||||||||||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||||||||||||||||||
Place of Publication: | ABINGDON | ||||||||||||||||||||||||||||
ISSN: | 1744-8328 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/12408 |
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