Universität zu Köln

Proschinger, Sebastian, Joisten, Niklas, Rademacher, Annette, Schlagheck, Marit L., Walzik, David, Metcalfe, Alan J., Oberste, Max, Warnke, Clemens, Bloch, Wilhelm, Schenk, Alexander, Bansi, Jens and Zimmer, Philipp (2019). Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis - a community-based randomized controlled trial. BMC Neurol., 19 (1). LONDON: BMC. ISSN 1471-2377

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Abstract

Background The relevance of regular moderate to intense exercise for ameliorating psychomotor symptoms in persons with multiple sclerosis (pwMS) is becoming increasingly evident. Over the last two decades, emerging evidence from clinical studies and animal models indicate immune regulatory mechanisms in both periphery and the central nervous system that may underlie these beneficial effects. The integrity of the blood-brain barrier as the main structural interface between periphery and brain seems to play an important role in MS. Reducing the secretion of proteolytic matrix metalloproteinases (MMP), i.e. MMP-2, as disruptors of blood-brain barrier integrity could have profound implications for MS. Methods In this two-armed randomized controlled trial 64 participants with relapsing-remitting MS (RRMS) (EDSS 0-4.0) will be allocated to either an intervention group or a passive wait list control group. The intervention group will perform 60 min of combined functional resistance and endurance exercises 3x per week over a period of 12 weeks in a community-based and publicly available setting. Changes in serum concentration of MMP-2 will be the primary outcome. Secondary outcomes are numbers of immune cell subsets, soluble (anti-) inflammatory factors, physical capacity, cognitive performance, physical activity behavior, gait performance, and patient-reported outcomes. All outcome measures will be assessed at baseline and after week 12 with an additional blood sampling before, during and immediately after a single training session in week 6. Discussion To our knowledge, this will be the first RCT to investigate both the acute and chronic effects of a community-based intense functional resistance and endurance exercise regimen in persons with RRMS. Combining analysis of biological and cognitive or psychological outcomes may provide a better understanding of the MS-specific symptomology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Proschinger, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rademacher, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlagheck, Marit L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walzik, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Metcalfe, Alan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberste, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Bansi, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124694
DOI:	10.1186/s12883-019-1544-7
Journal or Publication Title:	BMC Neurol.
Volume:	19
Number:	1
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2377
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHYSICAL-ACTIVITY; NEUROFILAMENT LIGHT; RECOMMENDATIONS; IMPAIRMENT; VALIDATION; SAMPLES; BRAIN; SCALE; CHAIN; CELL Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12469