Bittner, Stefan, Engel, Sinah, Lange, Christoph, Weber, Martin S., Haghikia, Aiden, Luessi, Felix, Korn, Thomas, Klotz, Luisa, Bayas, Antonios, Paul, Friedemann, Heesen, Christoph, Stangel, Martin, Wildemann, Brigitte, Bergh, Florian Then, Tackenberg, Bjoern, Trebst, Corinna, Warnke, Clemens, Linker, Ralf, Kerschensteiner, Martin, Zettl, Uwe, Tumani, Hayrettin, Brueck, Wolfgang, Meuth, Sven G., Kuempfel, Tanja, Hemmer, Bernhard, Wiendl, Heinz, Gold, Ralf and Zipp, Frauke (2019). Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis. Current status and recommendations in Germany. Nervenarzt, 90 (12). S. 1245 - 1254. NEW YORK: SPRINGER. ISSN 1433-0407

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Abstract

After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bittner, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, SinahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Martin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haghikia, AidenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luessi, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korn, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klotz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayas, AntoniosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stangel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wildemann, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergh, Florian ThenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tackenberg, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trebst, CorinnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linker, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerschensteiner, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zettl, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tumani, HayrettinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brueck, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meuth, Sven G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuempfel, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiendl, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gold, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zipp, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-125012
DOI: 10.1007/s00115-019-0760-0
Journal or Publication Title: Nervenarzt
Volume: 90
Number: 12
Page Range: S. 1245 - 1254
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1433-0407
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LATENT TUBERCULOSIS; STRATIFICATION; RIFAMPINMultiple languages
Clinical Neurology; PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12501

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