Universität zu Köln

Parveen, Farzana, Bender, Daniel, Law, Shi-Hui, Mishra, Vineet Kumar, Chen, Chih-Chieh ORCID: 0000-0002-5844-8428 and Ke, Liang-Yin ORCID: 0000-0002-2547-0987 (2019). Role of Ceramidases in Sphingolipid Metabolism and Human Diseases. Cells, 8 (12). BASEL: MDPI. ISSN 2073-4409

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Abstract

Human pathologies such as Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases have altered lipid homeostasis. Among these imbalanced lipids, the bioactive sphingolipids ceramide and sphingosine-1 phosphate (S1P) are pivotal in the pathophysiology of these diseases. Several enzymes within the sphingolipid pathway contribute to the homeostasis of ceramide and S1P. Ceramidase is key in the degradation of ceramide into sphingosine and free fatty acids. In humans, five different ceramidases are known-acid ceramidase, neutral ceramidase, and alkaline ceramidase 1, 2, and 3-which are encoded by five different genes (ASAH1, ASAH2, ACER1, ACER2, and ACER3, respectively). Notably, the neutral ceramidase N-acylsphingosine amidohydrolase 2 (ASAH2) shows considerable differences between humans and animals in terms of tissue expression levels. Besides, the subcellular localization of ASAH2 remains controversial. In this review, we sum up the results obtained for identifying gene divergence, structure, subcellular localization, and manipulating factors and address the role of ASAH2 along with other ceramidases in human diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Parveen, Farzana UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Law, Shi-Hui UNSPECIFIED UNSPECIFIED UNSPECIFIED Mishra, Vineet Kumar UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Chih-Chieh UNSPECIFIED orcid.org/0000-0002-5844-8428 UNSPECIFIED Ke, Liang-Yin UNSPECIFIED orcid.org/0000-0002-2547-0987 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125448
DOI:	10.3390/cells8121573
Journal or Publication Title:	Cells
Volume:	8
Number:	12
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN ACID CERAMIDASE; HUMAN ALKALINE CERAMIDASE; SPINAL MUSCULAR-ATROPHY; SATURATED FATTY-ACIDS; NEUTRAL CERAMIDASE; INSULIN-RESISTANCE; MOLECULAR-CLONING; OXIDATIVE STRESS; CELL-PROLIFERATION; FARBERS DISEASE Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12544