Universität zu Köln

Lennartz, Simon, Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Zopfs, David ORCID: 0000-0001-9978-7453, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Neuhaus, Victor-Frederic, Persigehl, Thorsten, Haneder, Stefan and Hokamp, Nils Grosse (2019). Intra-individual consistency of spectral detector CT-enabled iodine quantification of the vascular and renal blood pool. Eur. Radiol., 29 (12). S. 6581 - 6591. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives The objective of this study was to evaluate the intra-individual, longitudinal consistency of iodine measurements regarding the vascular and renal blood pool in patients that underwent repetitive spectral detector computed tomography (SDCT) examinations to evaluate their utility for oncologic imaging. Methods Seventy-nine patients with two (n=53) or three (n=26) clinically indicated biphasic SDCT scans of the abdomen were retrospectively included. ROI-based measurements of Hounsfield unit (HU) attenuation in conventional images and iodine concentration were performed by an experienced radiologist in the following regions (two ROIs each): abdominal aorta, vena cava inferior, portal vein, and renal cortices. Modified variation coefficients (MVCs) were computed to assess intra-individual longitudinal between the different time points. Results Variation of HU attenuation and iodine concentration measurements was significantly lower in the venous than in the arterial phase images (attenuation/iodine concentration: arterial -4.2/-3.9, venous 0.4/1.0; p pound 0.05). Regarding attenuation in conventional images of the arterial phase, the median MVC was -1.8 (-20.5-21.3) % within the aorta and -6.5 (-44.0-25.0) % within the renal cortex while in the portal venous phase, it was 0.62 (-11.1-11.7) % and -1.6 (-16.2-10.6) %, respectively. Regarding iodine concentration, MVC for arterial phase was -2.5 (-22.9-28.4) % within the aorta and -5.8 (-55.9-29.6) % within the renal cortex. The referring MVCs of the portal venous phase were -0.7 (-17.9-16.9) % and -2.6 (-17.6-12.5) %. Conclusions Intra-individual iodine quantification of the vascular and cortical renal blood pool at different time points works most accurately in venous phase images whereas measurements conducted in arterial phase images underlay greater variability.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdullayev, Nuran UNSPECIFIED orcid.org/0000-0003-4522-537X UNSPECIFIED Zopfs, David UNSPECIFIED orcid.org/0000-0001-9978-7453 UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Neuhaus, Victor-Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125940
DOI:	10.1007/s00330-019-06266-w
Journal or Publication Title:	Eur. Radiol.
Volume:	29
Number:	12
Page Range:	S. 6581 - 6591
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DUAL-ENERGY CT; COMPUTED-TOMOGRAPHY; CARCINOMA; ACCURACY; CELL; COEFFICIENT; METASTASES; CRITERIA; ALLOWS; MAPS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12594