Universität zu Köln

Froelich, Jan, Wiater, Alfred and Lehmkuhl, Gerd (2019). Melatonin in the treatment of neuropsychiatric diseases in children and adolescents. Somnologie, 23 (4). S. 271 - 281. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG. ISSN 1439-054X

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Abstract

Background Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and diverse rare neuropsychiatric disorders with psychomental retardation are often accompanied by comorbid problems concerning sleep onset and sleep maintenance. Measures of psychoeducation, sleep hygiene, and behavioral treatment remain the primary treatment of choice. However if these approaches are not effective, medical treatment with melatonin may be an additional treatment alternative. Objective and methods Based on Medline research, this article presents melatonin treatment results from metaanalyses, controlled treatment studies, and reviews. Results In particular, we discuss the indication and duration of treatment regarding chronic sleep problems in neuropsychiatric disorders as well as the fact that in many cases the medical treatment of the primary disorder may influence the patient's sleep. Additionally, possible interactions between melatonin and other medications may occur. Conclusion We conclude that melatonin is an effective and safe treatment option for sleep problems in neuropsychiatric diseases, if always implemented using a multimodal approach and, if possible, in an interval-related manner.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Froelich, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiater, Alfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmkuhl, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126061
DOI:	10.1007/s11818-019-0208-6
Journal or Publication Title:	Somnologie
Volume:	23
Number:	4
Page Range:	S. 271 - 281
Date:	2019
Publisher:	SPRINGER INTERNATIONAL PUBLISHING AG
Place of Publication:	CHAM
ISSN:	1439-054X
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS; PROLONGED-RELEASE MELATONIN; SLEEP PROBLEMS; CLOCK GENE; 3'-UNTRANSLATED REGION; STIMULANT MEDICATION; CONTROLLED-TRIAL; ADHD Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12606