Universität zu Köln

Altay, L., Sitnilska, V., Schick, T., Widmer, G., Duchateau-Nguyen, G., Piraino, P., Jayagopal, A., Drawnel, F. M. and Fauser, S. (2019). Early local activation of complement in aqueous humour of patients with age-related macular degeneration. Eye, 33 (12). S. 1859 - 1865. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5454

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Abstract

Objective To investigate complement activation in aqueous humour of patients with early, intermediate and neovascular age-related macular degeneration (AMD). Patients and methods Aqueous humour of 79 AMD patients (early, intermediate and neovascular) and 77 age-matched controls was prospectively collected. The levels of the complement protein 3 (C3), activation products complement factor 3a (C3a) and Ba, C3b/iC3b, complement factors B, H and I (CFB, CFH and CFI), and total protein concentration were measured. Data were modelled using covariate analysis to assess the impact of age and glaucoma status of patients and total protein concentration of samples on complement protein concentration across groups. Results C3a concentration was significantly increased in the aqueous humour of early (p = 0.016), intermediate (p = 0.003) and neovascular (p = 0.018) AMD patients, whilst C3 concentration was significantly increased in early AMD patients only (p = 0.019). Levels of CFB and CFH were significantly increased in the aqueous humour of neovascular AMD patients (p = 0.023 and p = 0.018, respectively). Conclusions Our findings provide evidence for early local complement dysregulation in AMD patients, suggesting that complement pathway inhibition may be a clinically relevant intervention for early stages of AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Altay, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sitnilska, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Widmer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duchateau-Nguyen, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piraino, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jayagopal, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drawnel, F. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126225
DOI:	10.1038/s41433-019-0501-4
Journal or Publication Title:	Eye
Volume:	33
Number:	12
Page Range:	S. 1859 - 1865
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BASAL DEPOSITS; RPE CELLS; FACTOR-H; RISK; RARE; C3A Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12622