Universität zu Köln

Gonzalez Campo, Cecilia, Salamone, Paula C., Rodriguez-Arriagada, Nicolas, Richter, Fabian, Herrera, Eduar ORCID: 0000-0001-9409-245X, Bruno, Diana, Pagani Cassara, Fatima, Sinay, Vladimiro, Garcia, Adolfo M., Ibanez, Agustin and Sedeno, Lucas . Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities. Mult. Scler. J.. LONDON: SAGE PUBLICATIONS LTD. ISSN 1477-0970

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Abstract

Background: Fatigue ranks among the most common and disabling symptoms in multiple sclerosis (MS). Recent theoretical works have surmised that this trait might be related to alterations across interoceptive mechanisms. However, this hypothesis has not been empirically evaluated. Objectives: To determine whether fatigue in MS patients is associated with specific behavioral, structural, and functional disruptions of the interoceptive domain. Methods: Fatigue levels were established via the Modified Fatigue Impact Scale. Interoception was evaluated through a robust measure indexed by the heartbeat detection task. Structural and functional connectivity properties of key interoceptive hubs were tested by magnetic resonance imaging (MRI) and resting-state functional MRI. Machine learning analyses were employed to perform pairwise classifications. Results: Only patients with fatigue presented with decreased interoceptive accuracy alongside decreased gray matter volume and increased functional connectivity in core interoceptive regions, the insula, and the anterior cingulate cortex. Each of these alterations was positively associated with fatigue. Finally, machine-learning analysis with a combination of the above interoceptive indices (behavioral, structural, and functional) successfully discriminated (area under the curve > 90%) fatigued patients from both non-fatigued and healthy controls. Conclusion: This study offers unprecedented evidence suggesting that disruptions of neurocognitive markers subserving interoception may constitute a signature of fatigue in MS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gonzalez Campo, Cecilia UNSPECIFIED UNSPECIFIED UNSPECIFIED Salamone, Paula C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez-Arriagada, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrera, Eduar UNSPECIFIED orcid.org/0000-0001-9409-245X UNSPECIFIED Bruno, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagani Cassara, Fatima UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinay, Vladimiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia, Adolfo M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ibanez, Agustin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sedeno, Lucas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126939
DOI:	10.1177/1352458519888881
Journal or Publication Title:	Mult. Scler. J.
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1477-0970
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR CINGULATE CORTEX; GLOBAL SIGNAL; CONNECTIVITY; IMPAIRMENTS; DISABILITY; ATROPHY; LESIONS Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12693