Jurisic, Stjepan, Gili, Sebastiano, Cammann, Victoria L., Kato, Ken ORCID: 0000-0001-6993-5152, Szawan, Konrad A., D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Jaguszewski, Milosz, Bossone, Eduardo, Citro, Rodolfo, Sarcon, Annahita, Napp, L. Christian ORCID: 0000-0001-9945-0842, Franke, Jennifer, Noutsias, Michel, Knorr, Maike, Heiner, Susanne, Burgdorf, Christof, Koenig, Wolfgang, Pott, Alexander, Kherad, Behrouz, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Meyer, Philippe, Arroja, Jose David, Banning, Adrian ORCID: 0000-0002-2842-7861, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Dworakowski, Rafal, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Dichtl, Wolfgang, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clement, Lairez, Olivier, Kozel, Martin, Tousek, Petr, Winchester, David E., Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Galuszka, Jan, Ukena, Christian, Poglajen, Gregor ORCID: 0000-0003-1777-8807, Paolini, Carla, Bilato, Claudio ORCID: 0000-0003-3474-0579, Carrilho-Ferreira, Pedro, Pinto, Fausto J., Opolski, Grzegorz, MacCarthy, Philip, Kobayashi, Yoshio, Prasad, Abhiram, Rihal, Charanjit S., Widimsky, Petr, Horowitz, John D., Di Mario, Carlo, Crea, Filippo, Tschope, Carsten, Pieske, Burkert M., Hasenfuss, Gerd, Rottbauer, Wolfgang, Braun-Dullaeus, Ruediger C., Felix, Stephan B., Borggrefe, Martin, Thiele, Holger, Bauersachs, Johann, Katus, Hugo A., Schunkert, Heribert, Muenzel, Thomas, Bohm, Michael, Bax, Jeroen J., Luscher, Thomas F., Ruschitzka, Frank, Ghadri, Jelena R. and Templin, Christian (2019). Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry. J. Am. Heart Assoc., 8 (21). HOBOKEN: WILEY. ISSN 2047-9980

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Abstract

Background-Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results-TTS patients from the International Takotsubo Registry were included in this study. Cut-off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In-hospital outcomes and 1-year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1-year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions-TTS patients without early LV recovery have different clinical characteristics and less favorable 1-year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jurisic, StjepanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gili, SebastianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kato, KenUNSPECIFIEDorcid.org/0000-0001-6993-5152UNSPECIFIED
Szawan, Konrad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDorcid.org/0000-0002-6646-9317UNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bossone, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Citro, RodolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, L. ChristianUNSPECIFIEDorcid.org/0000-0001-9945-0842UNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noutsias, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiner, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pott, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kherad, BehrouzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arroja, Jose DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDorcid.org/0000-0002-2842-7861UNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobza, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bridgman, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beug, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tousek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winchester, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarova, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shilova, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarov, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Battrawy, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akin, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galuszka, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poglajen, GregorUNSPECIFIEDorcid.org/0000-0003-1777-8807UNSPECIFIED
Paolini, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilato, ClaudioUNSPECIFIEDorcid.org/0000-0003-3474-0579UNSPECIFIED
Carrilho-Ferreira, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, Fausto J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobayashi, YoshioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rihal, Charanjit S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Widimsky, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horowitz, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Mario, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschope, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieske, Burkert M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borggrefe, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muenzel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luscher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-128167
DOI: 10.1161/JAHA.118.011194
Journal or Publication Title: J. Am. Heart Assoc.
Volume: 8
Number: 21
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2047-9980
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARDIOMYOPATHY; MORTALITY; OUTCOMES; PROFILEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12816

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