Universität zu Köln

Brinkmann, Sebastian, Noordman, Bo J., Hoelscher, Arnulf H., Biermann, Katharina, van Klaveren, David, Bollschweiler, Elfriede, Puetz, Katharina, van Lanschot, J. Jan B. and Drebber, Uta (2020). External Validation of Pretreatment Pathological Tumor Extent in Patients with Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer. Ann. Surg. Oncol., 27 (4). S. 1250 - 1259. NEW YORK: SPRINGER. ISSN 1534-4681

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Abstract

Background This study was conducted to validate a pretreatment (i.e. prior to neoadjuvant chemoradiotherapy) pathological staging system in the resection specimen after neoadjuvant chemoradiotherapy for esophageal cancer. The study investigated the prognostic value of pretreatment pathological T and N categories (prepT and prepN categories) in both an independent and a combined patient cohort. Methods Patients with esophageal cancer treated with neoadjuvant chemotherapy and esophagectomy between 2012 and 2015 were included. PrepT and prepN categories were estimated based on the extent of tumor regression and regressional changes of lymph nodes in the resection specimen. The difference in Akaike's information criterion (Delta AIC) was used to assess prognostic performance. PrepN and ypN categories were combined to determine the effect of nodal sterilization on prognosis. A multivariable Cox regression model was used to identify combined prepN and ypN categories as independent prognostic factors. Results The prognostic strength of the prepT category was better than the cT and ypT categories (Delta AIC 7.7 vs. 3.0 and 2.9, respectively), and the prognostic strength of the prepN category was better than the cN category and similar to the ypN category (Delta AIC 29.2 vs. - 1.0 and 27.9, respectively). PrepN + patients who became ypN0 had significantly worse survival than prepN0 patients (2-year overall survival 69% vs. 86% in 137 patients; p = 0.044). Similar results were found in a combined cohort of 317 patients (2-year overall survival 62% vs. 85%; p = 0.002). Combined prepN/ypN stage was independently associated with overall survival. Conclusions These results independently confirm the prognostic value of prepTNM staging. PrepTNM staging is of additional prognostic value to cTNM and ypTNM. PrepN0/ypN0 patients have a better survival than prepN +/ypN0 patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brinkmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Noordman, Bo J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Biermann, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED van Klaveren, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Puetz, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED van Lanschot, J. Jan B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128181
DOI:	10.1245/s10434-019-08024-0
Journal or Publication Title:	Ann. Surg. Oncol.
Volume:	27
Number:	4
Page Range:	S. 1250 - 1259
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1534-4681
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREOPERATIVE CHEMORADIOTHERAPY; ENDOSCOPIC ULTRASOUND; REGRESSION; THERAPY; RADIOCHEMOTHERAPY; CHEMORADIATION; CLASSIFICATION Multiple languages Oncology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12818