Universität zu Köln

Pachano, Tomas, Crispatzu, Giuliano and Rada-Iglesias, Alvaro (2019). Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells. Brief. Funct. Genomics, 18 (6). S. 358 - 367. OXFORD: OXFORD UNIV PRESS. ISSN 2041-2657

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Abstract

Polycomb group proteins (PcGs) control the epigenetic and transcriptional state of developmental genes and regulatory elements during mammalian embryogenesis. Moreover, PcGs can also contribute to 3D genome organization, adding an additional layer of complexity to their regulatory functions. Understanding the mechanistic basis and the dynamics of PcG-dependent chromatin structures will help us untangle the full complexity of PcG function during development. Since most studies concerning the 3D organization of PcG-bound chromatin in mammals have been performed in embryonic stem cells (ESCs), here we will focus on this cell type characterized by its unique self-renewal and pluripotency properties. More specifically, we will highlight recent findings and discuss open questions regarding how PcG-dependent changes in 3D chromatin architecture control gene expression, cellular identity and differentiation potential in ESCs. We believe that this can serve to illustrate the diverse regulatory mechanisms by which PcG proteins control the proper execution of gene expression programs during mammalian embryogenesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pachano, Tomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Crispatzu, Giuliano UNSPECIFIED UNSPECIFIED UNSPECIFIED Rada-Iglesias, Alvaro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128436
DOI:	10.1093/bfgp/elz022
Journal or Publication Title:	Brief. Funct. Genomics
Volume:	18
Number:	6
Page Range:	S. 358 - 367
Date:	2019
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2041-2657
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHROMATIN-STRUCTURE; SAM DOMAIN; LAMIN A/C; COMPLEX; COHESIN; PRC1; TRANSCRIPTION; ORGANIZATION; PROMOTER; ELEMENTS Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12843