Gravesande, Karin Storm Van's, Blaschek, Astrid, Calabrese, Pasquale, Rostasy, Kevin, Huppke, Peter, Kessler, Josef J., Kalbe, Elke, Mall, Volker, Kraus, V, Dornfeld, E., Elpers, C., Lohmann, H., Weddige, A., Hagspiel, S., Kirschner, J., Brehm, M., Blank, C., Schubert, J., Schimmel, M., Pachee, S., Mohrbach, M., Karenfort, M., Kamp, G., Luecke, T., Neumann, H., Lutz, S., Gierse, A., Sievers, S., Schiffinann, H., de Soye, I, Trollmann, R., Candova, A., Rosner, M., Neu, A., Romer, G., Seidel, U., John, R., Hofmann, C., Kinder, S., Bertolatus, A., Scheidtmann, K., Lasogga, R., Leiz, S., Alber, M., Kranz, J., Bajer-Kornek, B., Seidl, R. and Novak, A. (2019). Fatigue and depression predict health-related quality of life in patients with pediatric-onset multiple sclerosis. Mult. Scler. Relat. Disord., 36. OXFORD: ELSEVIER SCI LTD. ISSN 2211-0356

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Abstract

Background: Fatigue, depression and loss in health-related quality of life (HRQoL) have been reported to occur in a substantial amount of patients with pediatric-onset MS (POMS). This study aims to evaluate depression, fatigue and HRQoL and its relationship in a cohort of patients with POMS and matched healthy controls (HCs). Methods: In a multicenter cross-sectional study, Beck Depression Inventory II, Depressionstest fur Kinder, the Pediatric Quality of Life Inventory (PedsQL (TM)) 4.0 Generic Core Scale and the PedsQL (TM) Multidimensional Fatigue Scale were performed. Results: In a cohort of 106 patients with POMS and 210 matched HCs, patients were significantly more often depressed (21.7% vs. 11.4%, p = 0.014) experienced greater fatigue (40.6% vs. 17.3%, p < 0.001) and a greater loss of HRQoL (43.4% vs. 15%, p < 0.001) than controls. Depression predicted 51.8% of variance of fatigue. Fatigue was also predicted by female gender. Loss of HRQoL was predicted by EDSS, depression and fatigue. Depression and fatigue together explained 67.7% of variance of HRQoL. Conclusion: Patients with POMS are at a significant increased risk for depression, fatigue and loss of HRQoL. Furthermore, fatigue and depression significantly predict reduced HRQoL in POMS, suggesting that testing for these symptoms and early therapy is of utmost importance in all patients with POMS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gravesande, Karin Storm Van'sUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blaschek, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calabrese, PasqualeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rostasy, KevinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huppke, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, Josef J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mall, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraus, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dornfeld, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elpers, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohmann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weddige, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagspiel, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirschner, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brehm, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schimmel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pachee, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohrbach, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karenfort, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamp, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luecke, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lutz, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gierse, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sievers, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiffinann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Soye, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trollmann, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candova, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neu, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofmann, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kinder, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolatus, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheidtmann, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasogga, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leiz, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alber, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bajer-Kornek, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidl, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-128826
DOI: 10.1016/j.msard.2019.08.010
Journal or Publication Title: Mult. Scler. Relat. Disord.
Volume: 36
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 2211-0356
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PSYCHOSOCIAL FEATURES; CHILDHOOD; CHILDREN; ADOLESCENTS; RELIABILITY; PEDSQL(TM); VERSIONMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12882

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