Universität zu Köln

Schapowal, Andreas, Dobos, Gustav, Cramer, Holger, Ong, Kian Chung, Adler, Martin, Zimmermann, Andrea, Brandes-Schramm, Juliette and Lehmacher, Walter (2019). Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis. Heliyon, 5 (11). OXFORD: ELSEVIER SCI LTD. ISSN 2405-8440

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Abstract

The efficacy of Pelargonium si doi des preparation EPs 7630 in the common cold (CC) was assessed by performing meta-analyses of randomized, double-blind, placebo-controlled trials. Mean differences (MD) and risk ratios (RR) with their 95% confidence intervals (CI) were computed. Five trials with a total of 833 patients were included. All trials had a treatment period of ten days with visits at days 3, 5, and 10 after baseline and used a ten-symptom Cold Intensity Score (CIS) as the primary outcome. Significant differences favoring EPs 7630 were observed for total CIS reduction (day 5: MD = -2.30; 95%CI = -4.12,-0-49; day 10: MD = -1.16; 95%CI = -2.22,-0-10), proportion of patients with substantial improvement (day 5: RR = 1.73; day 10: RR = 1-06) and complete remission (day 5: RR = 2.52; day 10: RR = 2-13). Subjects treated with EPs 7630 missed fewer days at work, used less paracetamol and had an improved sleep quality. No serious adverse reactions to EPs 7630 were reported. The results support the efficacy of EPs 7630 in adults with CC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schapowal, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dobos, Gustav UNSPECIFIED UNSPECIFIED UNSPECIFIED Cramer, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Ong, Kian Chung UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmermann, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandes-Schramm, Juliette UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmacher, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128881
DOI:	10.1016/j.heliyon.2019.e02904
Journal or Publication Title:	Heliyon
Volume:	5
Number:	11
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2405-8440
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOUBLE-BLIND; PELARGONIUM-SIDOIDES; SELF-MEDICATION; ECONOMIC BURDEN; EFFICACY; PREVENTION; ECHINACEA; INFECTIONS; EXTRACT Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12888