Universität zu Köln

Pagni, Fabio ORCID: 0000-0001-9625-1637, Guerini-Rocco, Elena, Schultheis, Anne Maria, Grazia, Giulia, Rijavec, Erika, Ghidini, Michele ORCID: 0000-0001-5435-1218, Lopez, Gianluca, Venetis, Konstantinos, Croci, Giorgio Alberto, Malapelle, Umberto ORCID: 0000-0003-3211-9957 and Fusco, Nicola ORCID: 0000-0002-9101-9131 (2019). Targeting Immune-Related Biological Processes in Solid Tumors: We do Need Biomarkers. Int. J. Mol. Sci., 20 (21). BASEL: MDPI. ISSN 1422-0067

Full text not available from this repository.

Abstract

Immunotherapy has become the standard-of-care in many solid tumors. Despite the significant recent achievements in the diagnosis and treatment of cancer, several issues related to patients' selection for immunotherapy remain unsolved. Multiple lines of evidence suggest that, in this setting, the vision of a single biomarker is somewhat naive and imprecise, given that immunotherapy does not follow the rules that we have experienced in the past for targeted therapies. On the other hand, additional immune-related biomarkers that are reliable in real-life clinical practice remain to be identified. Recently, the immune-checkpoint blockade has been approved in the US irrespective of the tumor site of origin. Further histology-agnostic approvals, coupled with with tumor-specific companion diagnostics and guidelines, are expected in this field. In addition, immune-related biomarkers can also have a significant prognostic value. In this review, we provide an overview of the role of these biomarkers and their characterization in the management of lung cancer, melanoma, colorectal cancer, gastric cancer, head and neck cancer, renal cell carcinoma, urothelial cancers, and breast cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pagni, Fabio UNSPECIFIED orcid.org/0000-0001-9625-1637 UNSPECIFIED Guerini-Rocco, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultheis, Anne Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Grazia, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rijavec, Erika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghidini, Michele UNSPECIFIED orcid.org/0000-0001-5435-1218 UNSPECIFIED Lopez, Gianluca UNSPECIFIED UNSPECIFIED UNSPECIFIED Venetis, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Croci, Giorgio Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Malapelle, Umberto UNSPECIFIED orcid.org/0000-0003-3211-9957 UNSPECIFIED Fusco, Nicola UNSPECIFIED orcid.org/0000-0002-9101-9131 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-129002
DOI:	10.3390/ijms20215452
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	21
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPREHENSIVE MOLECULAR CHARACTERIZATION; METASTATIC UROTHELIAL CARCINOMA; CISPLATIN-INELIGIBLE PATIENTS; SQUAMOUS-CELL CARCINOMA; LIGAND 1 EXPRESSION; INFILTRATING LYMPHOCYTES; PD-L1 EXPRESSION; BREAST-CANCER; NASOPHARYNGEAL CARCINOMA; CHECKPOINT INHIBITORS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12900